Antigen cross-presentation in dendric cells: From bench to bedside

被引：7
作者：
Zhang, Tingting [1 ]
Aipire, Adila [1 ]
Li, Yijie [1 ]
Guo, Changying [1 ]
Li, Jinyao [1 ]
机构：
[1] Xinjiang Univ, Coll Life Sci & Technol, Xinjiang Key Lab Biol Resources & Genet Engn, Urumqi 830046, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 168卷
基金：
中国国家自然科学基金;
关键词：
Cross-presentation; Dendritic cells; MHC I; Antitumor; MHC CLASS-I; C-TYPE LECTIN; DC-SIGN; TRANSCRIPTIONAL REGULATOR; PHAGOSOME MATURATION; IMMUNE-RESPONSES; NECROTIC CELLS; PHASE-II; RECEPTOR; RECOGNITION;
D O I：
10.1016/j.biopha.2023.115758
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cross-presentation (XPT) is an adaptation of the cellular process in which dendritic cells (DCs) present exogenous antigens on major histocompatibility complex (MHC) class I molecules for recognition of the cytotoxic T lym-phocytes (CTL) and natural killer (NK) cells, resulting in immunity or tolerance. Recent advances in DCs have broadened our understanding of the underlying mechanisms of XPT and strengthened their application in tumor immunotherapy. In this review, we summarized the known mechanisms of XPT, including the receptor-mediated internalization of exogenous antigens, endosome escape, engagement of the other XPT-related proteins, and adjuvants, which significantly enhance the XPT capacity of DCs. Consequently, various strategies to enhance XPT can be adopted and optimized to improve outcomes of DC-based therapy.
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页数：11
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