Anti-inflammatory constituents from Bidens tripartita

被引：0

作者：

Jiang, Lihong ^{[1
]}

Wang, Hefei ^{[1
]}

Wang, Bangyong ^{[1
]}

Tan, Qingang ^{[1
,2
,3
]}

机构：

[1] Guilin Med Univ, Sch Pharmaceut Sci, Dept Med Chem, Guilin 541199, Peoples R China

[2] Guilin Med Univ, Guangxi Key Lab Drug Discovery & Optimizat, Guilin 541199, Peoples R China

[3] Guilin Med Univ, Guangxi Engn Res Ctr Pharmaceut Mol Screening & Dr, Guilin 541199, Peoples R China

来源：

TETRAHEDRON LETTERS | 2023年 / 130卷

基金：

中国国家自然科学基金;

关键词：

Asteraceae; Bidens tripartita; Flavonoids; NO inhibition activity; FLAVONOIDS; ANTIOXIDANT; STOKES; BARK;

D O I：

10.1016/j.tetlet.2023.154767

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bidens tripartita L., known as the herbal drug three-parted beggarticks of the Asteraceae family recorded in the ethnic medical treatise, is used for the treatment of inflammation-related diseases by ethnic minorities in China. Preliminary investigation showed that the ethyl ester extract of B. tripartita exhibited inhibitory activity on nitric oxide (NO) production using lipopolysaccharide (LPS)-stimulated murine macrophages. Phytochemical investigation of this extract afforded 21 compounds, including two new compounds (1 and 2), and their structures were determined by spectroscopic and mass spectrometric data. Anti-inflammatory bioassay showed that compounds 3, 7, 9, 10 and 13 significantly inhibited the production of NO with IC50 values of 17.60-25.69 mu M.

引用

页数：3

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