The Current Clinical Trial Landscape for Hidradenitis Suppurativa: A Narrative Review

被引：10

作者：

Hunt, Amanda ^{[1
]}

Qian, Victoria ^{[2
]}

Olds, Hailey ^{[3
]}

Daveluy, Steven ^{[3
]}

机构：

[1] Western Mchigan Univ Homer Stryker M D, Sch Med, 300 Portage St, Kalamazoo, MI 49007 USA

[2] Wayne State Univ, Sch Med, Detroit, MI 48202 USA

[3] Wayne State Univ, Sch Med, Dept Dermatol, Detroit, MI USA

来源：

DERMATOLOGY AND THERAPY | 2023年 / 13卷 / 07期

关键词：

Hidradenitis suppurativa; Clinical trials; Treatment; INHIBITOR;

D O I：

10.1007/s13555-023-00935-x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Hidradenitis suppurativa (HS) is a skin disease resulting from chronic, recurrent inflammation around hair follicles, characterized by proinflammatory cytokines such as IL-1, IL-17, IL-23, and TNF-alpha. While adalimumab, a TNF-alpha targeting human IgG monoclonal antibody, is the only approved treatment for HS, there are many other therapies being investigated now targeting other key players in inflammatory pathways such as the cytokines listed above, C5a in the complement pathway, and Janus kinase (JAK). This review discusses current clinical trials for biologics and small molecules, procedures, and wound dressings undergoing study in hidradenitis suppurativa.

引用

页码：1391 / 1407

页数：17

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