Adaptive radiotherapy for breast cancer

被引：10

作者：

De-Colle, C. ^{[1
,2
]}

Kirby, A. ^{[3
,4
]}

Russell, N. ^{[5
]}

Shaitelman, S. F. ^{[6
]}

Currey, A. ^{[7
]}

Donovan, E. ^{[8
]}

Hahn, E. ^{[9
]}

Han, K. ^{[9
]}

Anandadas, C. N. ^{[10
]}

Mahmood, F. ^{[11
]}

Lorenzen, E. L. ^{[11
]}

van den Bongard, D. ^{[12
]}

Koerkamp, M. L. Groot ^{[13
]}

Houweling, A. C. ^{[13
]}

Nachbar, M. ^{[2
,14
]}

Thorwarth, D. ^{[2
,14
,15
,16
]}

Zips, D. ^{[1
,2
,15
,16
]}

机构：

[1] Eberhard Karls Univ Tubingen, Univ Hosp, Dept Radiat Oncol, Tubingen, Germany

[2] Eberhard Karls Univ Tubingen, Med Fac, Tubingen, Germany

[3] Royal Marsden NHS Fdn Trust, Dept Radiotherapy, Sutton, Surrey, England

[4] Inst Canc Res, Sutton, Surrey, England

[5] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Radiotherapy, Amsterdam, Netherlands

[6] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX USA

[7] Med Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI USA

[8] Sunnybrook Hlth Sci Ctr, Odette Canc Ctr, Dept Radiat Oncol, Toronto, ON, Canada

[9] Princess Margaret Canc Ctr, Dept Radiat Oncol, Toronto, ON, Canada

[10] Christie NHS Fdn Trust, Dept Clin Oncol, Manchester, England

[11] Odense Univ Hosp, Dept Oncol, Odense, Denmark

[12] Amsterdam UMC, Dept Radiat Oncol, Amsterdam, Netherlands

[13] Univ Med Ctr Utrecht, Dept Radiat Oncol, Utrecht, Netherlands

[14] Eberhard Karls Univ Tubingen, Univ Hosp, Sect Biomed Phys, Dept Radiat Oncol, Tubingen, Germany

[15] German Canc Consortium DKTK, Partner Site Tubingen, Tubingen, Germany

[16] German Canc Res Ctr, Heidelberg, Germany

来源：

CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY | 2023年 / 39卷

关键词：

Breast cancer; Adaptive radiotherapy; Partial breast irradiation; MR-linac; TARGET VOLUME DELINEATION; MRI-GUIDED RADIOTHERAPY; SUPINE MAGNETIC-RESONANCE; RADIATION-THERAPY; COMPUTED-TOMOGRAPHY; CONSERVING THERAPY; LUMPECTOMY CAVITY; NEURAL-NETWORK; LINAC SYSTEMS; IRRADIATION;

D O I：

10.1016/j.ctro.2022.100564

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Research in the field of local and locoregional breast cancer radiotherapy aims to maintain excellent oncological outcomes while reducing treatment-related toxicity. Adaptive radiotherapy (ART) considers variations in target and organs at risk (OARs) anatomy occurring during the treatment course and integrates these in re-optimized treatment plans. Exploiting ART routinely in clinic may result in smaller target volumes and better OAR sparing, which may lead to reduction of acute as well as late toxicities. In this review MR-guided and CT-guided ART for breast cancer patients according to different clinical scenarios (neoadjuvant and adjuvant partial breast irradiation, whole breast, chest wall and regional nodal irradiation) are reviewed and their advantages as well as challenging aspects discussed.

引用

页数：7

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