Arterial oxygen and carbon dioxide tension and acute brain injury in extracorporeal cardiopulmonary resuscitation patients: Analysis of the extracorporeal life support organization registry

被引：28

作者：

Shou, Benjamin L. ^{[1
]}

Ong, Chin Siang ^{[2
]}

Premraj, Lavienraj ^{[3
,4
]}

Brown, Patricia ^{[1
]}

Tonna, Joseph E. ^{[5
,6
]}

Dalton, Heidi J. ^{[7
]}

Kim, Bo Soo ^{[8
]}

Keller, Steven P. ^{[8
,9
]}

Whitman, Glenn J. R. ^{[1
]}

Cho, Sung -Min ^{[1
,10
,11
,12
,13
,14
]}

机构：

[1] Johns Hopkins Univ, Dept Surg, Div Cardiac Surg, Sch Med, Baltimore, MD USA

[2] Yale Sch Med, Dept Surg, Div Surg Outcomes, New Haven, CT USA

[3] Griffith Univ, Sch Med, Gold Coast, Qld, Australia

[4] Prince Charles Hosp, Crit Care Res Grp, Brisbane, Qld, Australia

[5] Univ Utah Hlth, Dept Surg, Div Cardiothorac Surg, Salt Lake City, UT USA

[6] Univ Utah Hlth, Dept Emergency Med, Salt Lake City, UT USA

[7] INOVA Fairfax Med Ctr, Adult & Pediat Extracorporeal Life Support, Falls Church, VA USA

[8] Johns Hopkins Univ, Div Pulm & Crit Care Med, Sch Med, Baltimore, MD USA

[9] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA

[10] Johns Hopkins Univ, Dept Neurol Neurosurg Anesthesia & Crit Care Med, Div Neurosci Crit Care, Sch Med, Baltimore, MD USA

[11] Johns Hopkins Univ, Dept Neurol, Div Neurosci Crit Care, Div Cardiac Surg, 600 N Wolfe St,Phipps 455, Baltimore, MD 21287 USA

[12] Johns Hopkins Univ, Dept Neurosurg, Div Neurosci Crit Care, Div Cardiac Surg, 600 N Wolfe St,Phipps 455, Baltimore, MD 21287 USA

[13] Johns Hopkins Univ, Dept Surg, Div Neurosci Crit Care, Div Cardiac Surg, 600 N Wolfe St,Phipps 455, Baltimore, MD 21287 USA

[14] Johns Hopkins Univ, Dept Anesthesia & Crit Care Med, Div Neurosci Crit Care, Div Cardiac Surg, 600 N Wolfe St,Phipps 455, Baltimore, MD 21287 USA

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2023年 / 42卷 / 04期

关键词：

neurological injury; extracorporeal membrane oxygenation; ECPR; MEMBRANE-OXYGENATION; HYPEROXIC REPERFUSION; HEMORRHAGIC STROKES; CARDIAC-ARREST; RISK-FACTORS; OUTCOMES; FLOW;

D O I：

10.1016/j.healun.2022.10.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Acute brain injury (ABI) remains common after extracorporeal cardiopulmonary resuscitation (ECPR). Using a large international multicenter cohort, we investigated the impact of peri-cannulation arterial oxygen (PaO2) and carbon dioxide (PaCO2) on ABI occurrence. METHODS: We retrospectively analyzed adult (>= 18 years old) ECPR patients in the Extracorporeal Life Support Organization registry from 1/2009 through 12/2020. Composite ABI included ische-mic stroke, intracranial hemorrhage (ICH), seizures, and brain death. The registry collects 2 blood gas data pre-(6 hours) and post-(24 hours) cannulation. Blood gas parameters were classi-fied as: hypoxia (<60mm Hg), normoxia (60-119mm Hg), and mild (120-199mm Hg), moderate (200-299mm Hg), and severe hyperoxia (>= 300mm Hg); hypocarbia (<35mm Hg), normocarbia (35-44mm Hg), mild (45-54mm Hg) and severe hypercarbia (>= 55mm Hg). Missing values were handled using multiple imputation. Multivariable logistic regression analysis was used to assess the relationship of PaO2 and PaCO2 with ABI.

引用

页码：503 / 511

页数：9

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