The default mode network is associated with changes in internalizing and externalizing problems differently in adolescent boys and girls

被引：9

作者：

Lee, Yoonji ^{[1
]}

Chahal, Rajpreet ^{[1
]}

Gotlib, Ian H. ^{[1
]}

机构：

[1] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA

来源：

DEVELOPMENT AND PSYCHOPATHOLOGY | 2024年 / 36卷 / 02期

关键词：

adolescence; brain functional connectivity; externalizing; internalizing; sex differences; CORTICAL THICKNESS; DEPRESSION; BRAIN; DISORDERS; PSYCHOPATHOLOGY; CHILDHOOD; ATTENTION; VALIDITY; BEHAVIOR;

D O I：

10.1017/S0954579423000111

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Internalizing and externalizing problems that emerge during adolescence differentially increase boys' and girls' risk for developing psychiatric disorders. It is not clear, however, whether there are sex differences in the intrinsic functional architecture of the brain that underlie changes in the severity of internalizing and externalizing problems in adolescents. Using resting-state fMRI data and self-reports of behavioral problems obtained from 128 adolescents (73 females; 9-14 years old) at two timepoints, we conducted multivoxel pattern analysis to identify resting-state functional connectivity markers at baseline that predict changes in the severity of internalizing and externalizing problems in boys and girls 2 years later. We found sex-differentiated involvement of the default mode network in changes in internalizing and externalizing problems. Whereas changes in internalizing problems were associated with the dorsal medial subsystem in boys and with the medial temporal subsystem in girls, changes in externalizing problems were predicted by hyperconnectivity between core nodes of the DMN and frontoparietal network in boys and hypoconnectivity between the DMN and affective networks in girls. Our results suggest that different neural mechanisms predict changes in internalizing and externalizing problems in adolescent boys and girls and offer insights concerning mechanisms that underlie sex differences in the expression of psychopathology in adolescence.

引用

页码：834 / 843

页数：10

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