Enterococcus faecalis in secondary apical periodontitis: Mechanisms of bacterial survival and disease persistence

被引：31

作者：

Elashiry, Mohamed M. ^{[1
,2
,3
]}

Bergeron, Brian E. ^{[1
]}

Tay, Franklin R. ^{[1
]}

机构：

[1] Augusta Univ, Dent Coll Georgia, Dept Endodont, Augusta, GA USA

[2] Ain Shams Univ, Fac Dent, Dept Endodont, Cairo, Egypt

[3] Augusta Univ, Dent Coll Georgia, Dept Endodont, 1430 John Wesley Gilbert Dr, Augusta, GA 30912 USA

来源：

MICROBIAL PATHOGENESIS | 2023年 / 183卷

关键词：

Apical periodontitis; Bacterial persistence; Enterococcus faecalis; Immune cells; Virulence factors; POLYMERASE-CHAIN-REACTION; SURFACE PROTEIN ESP; BIOFILM FORMATION; AGGREGATION SUBSTANCE; VIRULENCE FACTORS; ROOT CANALS; INFLAMMATORY RESPONSES; INFECTIVE ENDOCARDITIS; ENDODONTIC INFECTIONS; MEDIATES ATTACHMENT;

D O I：

10.1016/j.micpath.2023.106337

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Enterococcus faecalis is a commensal bacterium commonly found in the human gastrointestinal tract. However, in individuals with compromised immune systems, the pathogen can lead to severe illness. This opportunistic pathogen is associated with secondary apical diseases and is adept at resisting antibiotics and other forms of treatment because of its numerous virulence factors. Enterococcus faecalis is capable of disrupting the normal functions of immune cells, thereby hindering the body's ability to eradicate the infection. However, intensive research is needed in further understanding the adverse immunomodulatory effects of E. faecalis. Potential strategies specific for eradicating E. faecalis have proven beneficial in the treatment of persistent secondary apical periodontitis.

引用

页数：9

共 146 条

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