Heart failure and diabetes: Understanding the bidirectional relationship

被引：23

作者：

Elendu, Chukwuka ^{[1
]}

Amaechi, Dependable C. ^{[2
]}

Elendu, Tochi C. ^{[3
]}

Ashna, Manizha ^{[4
]}

Ross-Comptis, Jennifer ^{[5
]}

Ansong, Sandra O. ^{[6
]}

Egbunu, Emmanuel O. ^{[7
]}

Okafor, Geraldine C. ^{[8
]}

Jingwa, Klein A. ^{[9
]}

Akintunde, Akinbayo A. ^{[10
]}

Ogah, Chidinma M. ^{[10
]}

Edeko, Melissa O. ^{[10
]}

Ibitoye, Ayodeji V. ^{[10
]}

Ogunseye, Mojetoluwa O. ^{[11
]}

Alakwe-Ojimba, Chisom E. ^{[12
]}

Omeludike, Eunice K. ^{[13
]}

Oguine, Chibuike A. ^{[10
]}

Afuh, Rechner N. ^{[14
]}

Olawuni, Clinton A. ^{[15
]}

Ekwem, Onyekachukwu R. ^{[16
]}

Oyedele, Boluwatife A. ^{[10
]}

Pius, Erica I. ^{[10
]}

Asekhauno, Mercy O. ^{[10
]}

Ladele, John A. ^{[10
]}

Okoro, Chinonso B. ^{[17
]}

Monika Pouekoua, Brandon C. ^{[18
]}

Adenikinju, Joseph S. ^{[19
]}

Agu-ben, Chigozirim M. ^{[20
]}

Aborisade, Ooreofe ^{[21
]}

机构：

[1] Fed Univ Teaching Hosp Owerri, Owerri 460281, Nigeria

[2] Igbinedion Univ, Okada, Nigeria

[3] Imo State Univ, Owerri, Nigeria

[4] Univ Ottawa, Ottawa, ON, Canada

[5] Larkin Community Hosp, Doral, FL USA

[6] Catholic Hosp Battor, Bator, Ghana

[7] Fed Med Ctr Bida, Bida, Nigeria

[8] Univ Nigeria Teaching Hosp, Enugu, Nigeria

[9] Kazan State Med Univ, Kazan, Russia

[10] Babcock Univ, Ilisan, Nigeria

[11] Natl Pirogov Mem Med Univ, Vinnytsia, Ukraine

[12] Chukwuemeka Odumegwu Ojukwu Univ, Uli, Atughobi, Nigeria

[13] Univ Port Harcourt, Port Harcourt, Nigeria

[14] Manor Hosp, Oxford, England

[15] Gen Hosp, Lagos, Nigeria

[16] Delta State Univ, Uruoka, Delta, Nigeria

[17] Fed Med Ctr Owerri, Owerri, Nigeria

[18] Univ Bamenda, Bamenda, Cameroon

[19] Northwick Pk Hosp London Northwest NHS Trust, Abuja, Nigeria

[20] Kharkiv Nationa Med Univ, Kharkiv, Ukraine

[21] Olabisi Onabanjo Univ Teaching Hosp, Shagamu, Nigeria

来源：

MEDICINE | 2023年 / 102卷 / 37期

关键词：

bidirectional relationship; diabetes mellitus; GLP-1 receptor agonists; heart failure; SGLT2; inhibitors; CARDIOVASCULAR OUTCOMES; RISK; COMPLICATION; ENALAPRIL; DISEASE;

D O I：

10.1097/MD.0000000000034906

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure and diabetes mellitus are 2 common and closely intertwined chronic conditions that often coexist in individuals. The relationship between heart failure and diabetes is bidirectional, meaning that each condition can influence the development and progression of the other. Understanding this complex interplay is crucial for optimizing the management and outcomes of patients with these comorbidities. This review comprehensively analyzed the literature to examine the bidirectional relationship between heart failure and diabetes. We searched various electronic databases and included studies that explored the pathophysiological mechanisms, epidemiology, clinical implications, and therapeutic considerations associated with this relationship. The bidirectional relationship between heart failure and diabetes is multifactorial and involves several interconnected mechanisms. Diabetes is a recognized risk factor for heart failure, increasing the risk of its development and accelerating its progression. On the other hand, heart failure can contribute to the development of insulin resistance and worsen glycemic control in patients with diabetes. Shared risk factors, such as obesity, hypertension, and dyslipidemia, contribute to development of both conditions. Additionally, hyperglycemia, insulin resistance, chronic inflammation, oxidative stress, and mitochondrial dysfunction play significant roles in the pathogenesis of heart failure in individuals with diabetes. The bidirectional relationship between heart failure and diabetes has important clinical implications. Patients with heart failure and diabetes have worse outcomes, including higher hospitalization rates, morbidity, and mortality, than those without diabetes. Optimal management strategies should target both conditions simultaneously, focusing on lifestyle modifications, pharmacotherapy, glycemic control, and cardiovascular risk reduction.

引用

页数：7

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