Trastuzumab deruxtecan (T-DXd) versus treatment of physician's choice (TPC) in patients (pts) with HER2-low unresectable and/or metastatic breast cancer (mBC): Updated survival results of the randomized, phase III DESTINY-Breast04 study

被引:16
作者
Modi, S. [1 ]
Jacot, W. [2 ]
Iwata, H. [3 ]
Park, Y. H. [4 ]
Vidal Losada, M. J. [5 ]
Li, W. [6 ]
Tsurutani, J. [7 ]
Zaman, K. [8 ]
Ueno, N. T. [9 ]
Prat, A. [10 ]
Papazisis, K. [11 ]
Rugo, H. S. [12 ]
Harbeck, N. [13 ]
Im, S-A. [14 ]
De Laurentiis, M. [15 ]
Orbegoso, C. M. A. [16 ]
Yung, L. [17 ]
Cheng, F-C. [18 ]
Cheng, Y. [19 ]
Cameron, D. A. [20 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Med, New York, NY USA
[2] Inst Canc Montpellier, Med Oncol, Montpellier, France
[3] Aichi Canc Ctr Hosp, Breast Oncol, Nagoya, Aichi, Japan
[4] Samsung Med Ctr, Hematol Oncol, Seoul, South Korea
[5] Hosp Clin Barcelona, Oncol Med, Barcelona, Spain
[6] First Hosp Jilin Univ, Tumor Ctr, Changchun, Jilin, Peoples R China
[7] Showa Univ, Adv Canc Translat Res Inst, Shinagawa, Japan
[8] Lausanne Univ Hosp CHUV, Oncol, Lausanne, Switzerland
[9] Univ Hawaii, Med, Ctr Canc, Honolulu, HI USA
[10] August Pi & Sunyer Biomed Res Inst IDIBAPS, Med Oncol, Translat Genom & Targeted Therapies Grp, Barcelona, Spain
[11] Euromed Gen Clin, Oncol, Thessaloniki, Greece
[12] UCSF, Med, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA
[13] LMU Univ Hosp, Breast Ctr, Obstet & Gynecol, Munich, Germany
[14] Seoul Natl Univ, Seoul Natl Univ Hosp, Internal Med, Coll Med, Seoul, South Korea
[15] Ist Nazl Tumori IRCCS Fdn G Pascale, Breast Oncol Unit, Naples, Italy
[16] Daiichi Sankyo Inc, Global Oncol Res & Dev, Rueil Malmaison, France
[17] Daiichi Sankyo Inc, Global Oncol R&D, Basking Ridge, NJ USA
[18] Daiichi Sankyo Inc, Biostat & Data Management, Basking Ridge, NJ USA
[19] Daiichi Sankyo Inc, Clin Safety & Pharmacovigilance, Basking Ridge, NJ USA
[20] Univ Edinburgh, Edinburgh Univ Canc Ctr, Edinburgh, Midlothian, Scotland
关键词
D O I
10.1016/j.annonc.2023.09.553
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
376O
引用
收藏
页码:S334 / S335
页数:2
相关论文
共 50 条
  • [31] Pooled analysis by best confirmed response to trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2+metastatic breast cancer (mBC) from DESTINY-Breast-01,-02, and-03
    Saura, Cristina
    Cortes, Javier
    Modi, Shanu
    Kim, Sung-Bae
    Hamilton, Erika P.
    Hurvitz, Sara A.
    Krop, Ian E.
    Curigliano, Giuseppe
    Iwata, Hiroji
    Im, Seock-Ah
    Herbolsheimer, Pia Maarit
    Karnoub, Maha
    Gambhire, Dhiraj
    Egorov, Anton
    Andre, Fabrice
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [32] Subgroup analysis by disease history and prior treatments of patients (pts) with HER2-positive (HER2+) metastatic breast cancer (MBC) from DESTINY-Breast03, a randomized phase III study of trastuzumab deruxtecan (T-DXd) vs trastuzumab emtansine (T-DM1)
    Cortes, J.
    Im, S-A.
    Iwata, H.
    Hamilton, E. P.
    Hurvitz, S. A.
    Egorov, A.
    Cathcart, J.
    Liu, Y.
    Bako, E.
    Curigliano, G.
    ANNALS OF ONCOLOGY, 2022, 33 (07) : S645 - S646
  • [33] Trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2+advanced/metastatic breast cancer (mBC) with or without brain metastases (BM): DESTINYBreast-12 primary results
    Lin, N.
    Ciruelos, E. M.
    Jerusalem, G.
    Mueller, V.
    Niikura, N.
    Viale, G.
    Bartsch, R.
    Kurzeder, C.
    Connolly, R.
    Baron-Hay, S. E.
    Cortes, M. Gion
    Guarneri, V.
    Bianchini, G.
    Wildiers, H.
    Escriva-de-Romani, S.
    Prahladan, M.
    Bridge, H.
    Verma, S.
    Harbeck, N.
    ANNALS OF ONCOLOGY, 2024, 35 : 1211 - 1212
  • [34] ALTER-BC-Ib-01: A prospective phase Ib study of anlotinib with trastuzumab deruxtecan (T-DXd) for HER2-low unresectable (u)/metastatic (m) breast cancer (BC)
    Meng, Y.
    Mu, Y.
    Zhang, J.
    ANNALS OF ONCOLOGY, 2024, 35 : S402 - S402
  • [35] Trastuzumab deruxtecan (T-DXd; DS-8201a) vs. trastuzumab emtansine (T-DM1) in patients (pts) with HER2+metastatic breast cancer (mBC): subgroup analyses from the randomized phase 3 study DESTINY-Breast03
    Hurvitz, Sara
    Kim, Sung-Bae
    Chung, Wei-Pang
    Im, Seock-Ah
    Park, Yeon Hee
    Hegg, Roberto
    Kim, Min-Hwan
    Tseng, Ling-Ming
    Petry, Vanessa
    Chung, Chi-Feng
    Iwata, Hiroji
    Hamilton, Erika
    Curigliano, Giuseppe
    Xu, Binghe
    Lee, Caleb
    Liu, Yali
    Cathcart, Jillian
    Bako, Emarjola
    Verma, Sunil
    Cortes, Javier
    CANCER RESEARCH, 2022, 82 (04)
  • [36] Analysis of study drug-related interstitial lung disease (ILD) in patients (pts) with HER2+metastatic breast cancer (mBC) treated with trastuzumab deruxtecan (T-DXd)
    Powell, C. A.
    Modi, S.
    Iwata, H.
    Takahashi, S.
    Nie, K.
    Qin, A.
    Singh, J.
    Taitt, C.
    Verma, S.
    Camidge, D. R.
    ANNALS OF ONCOLOGY, 2021, 32 : S61 - S62
  • [37] An age-specific pooled analysis of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-positive (HER2+) metastatic breast cancer (mBC) from DESTINY-Breast01,-02, and-03
    Krop, Ian E.
    Wildiers, Hans
    Hurvitz, Sara A.
    Cortes, Javier
    Im, Seock-Ah
    Iwata, Hiroji
    Andre, Fabrice
    Saura, Cristina
    Modi, Shanu
    Kim, Sung-Bae
    Egorov, Anton
    Mathias, Elton
    Cathcart, Jillian
    Cagnazzo, Antonio
    Cheng, Yingkai
    Park, Yeon Hee
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [38] A multicenter, prospective, observational study of patients receiving trastuzumab deruxtecan for the treatment of HER2-positive and HER2-low unresectable and/or metastatic breast cancer: DESTINY-Breast-RESPOND
    O'Shaughnessy, Joyce
    Basho, Reva
    Lustberg, Maryam
    Lyman, Gary H.
    Prahladan, Manoj
    James, Gareth D.
    Varghese, Della
    Lujan, Flavia
    Tesch, Hans
    CANCER RESEARCH, 2024, 84 (09)
  • [39] Trastuzumab deruxtecan (T-DXd) in patients with HER2+metastatic breast cancer with brain metastases: A subgroup analysis of the DESTINY-Breast01 trial.
    Jerusalem, Guy Heinrich Maria
    Park, Yeon Hee
    Yamashita, Toshinari
    Hurvitz, Sara A.
    Modi, Shanu
    Andre, Fabrice
    Krop, Ian E.
    Gonzalez, Xavier
    Hall, Peter S.
    You, Benoit
    Saura, Cristina
    Kim, Sung-Bae
    Osborne, Cynthia R. C.
    Sagara, Yasuaki
    Tokunaga, Eriko
    Liu, Yali
    Cathcart, Jillian
    Lee, Caleb C.
    Perrin, Christophe
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [40] A pooled analysis of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-positive (HER2+) metastatic breast cancer (mBC) with brain metastases (BMs) from DESTINY-Breast (DB)-01,-02, and-03
    Hurvitz, S. A.
    Modi, S.
    Li, W.
    Park, Y. H.
    Chung, W.
    Kim, S-B.
    Cortes, J.
    Yamashita, T.
    Pedrini, J.
    Im, S-A.
    Tseng, L-M.
    Harbeck, N.
    Krop, I.
    Curigliano, G.
    Mathias, E.
    Cathcart, J.
    Cagnazzo, A.
    Ashfaque, S.
    Egorov, A.
    Andre, F.
    ANNALS OF ONCOLOGY, 2023, 34 : S335 - S336