Reserach Advances on Nanozyme-Guided Therapy of Inflammatory Bowel Diseases

Recently, the increasing morbidity of inflammatory bowel diseases (IBD) has become a threat to public health around the world. At present, anti-inflammatory drugs, antibiotics, biological antibodies, and immunomodulators are widely used to treat IBD through suppressing inflammation response, but the therapeutic effects are not always satisfied. Biological enzymes have highly efficient and specific catalytic activity, which has aroused extensive research interest in diagnosis and treatment of inflammatory diseases. However, bioenzymes are difficult to be purified and are easy to be inactivated within organism, which limits its further applications. Compared with bioenzymes, nanozymes have simple preparation procedure, stable structure and high enzyme-like catalytic activity. Very recently, nanozymes have been widely used in the field of biomedicine, such as anti-cancer, antibacterial, anti-inflammation and so on. In this review, recent research advances of nanozymes for treatment of IBD are summarized by introducing typical studies, focusing on the composition, synthesis methods, catalytic properties and therapeutic mechanisms of the used nanozymes. This review also discusses the limitations of the current application of nanozymes for the treatment of IBD, and the prospect of the future construction of nanozymes for treatment of IBD.