FXR activation enhances ACE2 expression and inhibits viral-induced IL-6 release from colonic epithelial cells in vitro: implications for gastrointestinal symptoms of SARS-CoV-2

被引:0
|
作者
Smyth, Jessica
Truong, Jennifer
Rao, Anuradha
Foulke-Abel, Jennifer
Adorini, Luciano
Donowitz, Mark
Dawson, Paul
Keely, Stephen
机构
基金
美国国家卫生研究院; 爱尔兰科学基金会;
关键词
Covid; 19; ACE2; Farnesoid X Receptor; Inflammation;
D O I
10.1152/physiol.2023.38.S1.5733615
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
引用
收藏
页数:2
相关论文
共 24 条
  • [1] Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2
    Smyth, Jessica S.
    Truong, Jennifer K.
    Rao, Anuradha
    Lin, Ruxian
    Foulke-Abel, Jennifer
    Adorini, Luciano
    Donowitz, Mark
    Dawson, Paul A.
    Keely, Stephen J.
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2023, 325 (05): : G446 - G452
  • [2] SARS-CoV-2 tropism to intestinal but not gastric epithelial cells is defined by limited ACE2 expression
    Pauzuolis, Mindaugas
    Fatykhova, Diana
    Zueihlke, Boris
    Schwecke, Torsten
    Neyazi, Mastura
    Samperio-Ventayol, Pilar
    Aguilar, Carmen
    Schlegel, Nicolas
    Doeikel, Simon
    Ralser, Markus
    Hocke, Andreas
    Krempl, Christine
    Bartfeld, Sina
    STEM CELL REPORTS, 2024, 19 (05): : 629 - 638
  • [3] ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry?
    Scagnolari, Carolina
    Bitossi, Camilla
    Viscido, Agnese
    Frasca, Federica
    Oliveto, Giuseppe
    Scordio, Mirko
    Petrarca, Laura
    Mancino, Enrica
    Nenna, Raffaella
    Riva, Elisabetta
    De Vito, Corrado
    Midulla, Fabio
    Antonelli, Guido
    Pierangeli, Alessandra
    CYTOKINE, 2021, 140
  • [4] Epstein-Barr Virus Lytic Replication Induces ACE2 Expression and Enhances SARS-CoV-2 Pseudotyped Virus Entry in Epithelial Cells
    Verma, Dinesh
    Church, Trenton Mel
    Swaminathan, Sankar
    JOURNAL OF VIROLOGY, 2021, 95 (13)
  • [5] Expression of the SARS-CoV-2 Receptor ACE2 and Proinflammatory Cytokines Induced by the Periodontopathic Bacterium Fusobacterium nucleatum in Human Respiratory Epithelial Cells
    Takahashi, Yuwa
    Watanabe, Norihisa
    Kamio, Noriaki
    Yokoe, Sho
    Suzuki, Ryuta
    Sato, Shuichi
    Iinuma, Toshimitsu
    Imai, Kenichi
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (03) : 1 - 13
  • [6] Preliminary Evidence for IL-10-Induced ACE2 mRNA Expression in Lung-Derived and Endothelial Cells: Implications for SARS-Cov-2 ARDS Pathogenesis
    Albini, Adriana
    Calabrone, Luana
    Carlini, Valentina
    Benedetto, Nadia
    Lombardo, Michele
    Bruno, Antonino
    Noonan, Douglas M.
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [7] Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells
    Coutinho Almeida-da-Silva, Cassio Luiz
    Matshik Dakafay, Harmony
    Liu, Kaitlyn
    Ojcius, David M.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (14)
  • [8] Development of an in vitro model for animal species susceptibility to SARS-CoV-2 replication based on expression of ACE2 and TMPRSS2 in avian cells
    Kapczynski, Darrell R.
    Sweeney, Ryan
    Spackman, Erica
    Pantin-Jackwood, Mary
    Suarez, David L.
    VIROLOGY, 2022, 569 : 1 - 12
  • [9] SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells
    Patra, Tapas
    Meyer, Keith
    Geerling, Lizzie
    Isbell, T. Scott
    Hoft, Daniel F.
    Brien, James
    Pinto, Amelia K.
    Ray, Ratna B.
    Ray, Ranjit
    PLOS PATHOGENS, 2020, 16 (12)
  • [10] SARS-CoV-2 Spike Protein Suppresses ACE2 and Type I Interferon Expression in Primary Cells From Macaque Lung Bronchoalveolar Lavage
    Sui, Yongjun
    Li, Jianping
    Venzon, David J.
    Berzofsky, Jay A.
    FRONTIERS IN IMMUNOLOGY, 2021, 12