Potential Clinical Applications of Pro-Resolving Lipids Mediators from Docosahexaenoic Acid

被引：30
作者：
Beyer, Maria Paz [1 ]
Videla, Luis A. [2 ]
Farias, Camila [1 ]
Valenzuela, Rodrigo [1 ]
机构：
[1] Univ Chile, Fac Med, Dept Nutr, Santiago 8380000, Chile
[2] Univ Chile, Inst Biomed Sci, Fac Med, Mol & Clin Pharmacol Program, Santiago 7810000, Chile
来源：
NUTRIENTS | 2023年 / 15卷 / 15期
关键词：
docosahexaenoic acid; specialized pro-resolving mediators; anti-inflammation; resolvins series D; protectins; maresins; MARESIN; 1; BIOSYNTHESIS; EICOSAPENTAENOIC ACID; PROTECTIN D1; CARDIOVASCULAR-DISEASE; PARKINSONS-DISEASE; PROMOTE RESOLUTION; INFLUENZA-VIRUS; IMMUNE-RESPONSE; FATTY-ACIDS; INFLAMMATION;
D O I：
10.3390/nu15153317
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Docosahexaenoic acid (C22:6n-3, DHA) is the precursor of specialized pro-resolving lipid mediators (SPMs), such as resolvin, protectin, and maresin families which have been considered therapeutic bioactive compounds for human health. Growing evidence indicates that DHA and SPMs are beneficial strategies in the amelioration, regulation, and duration of inflammatory processes through different biological actions. The present review discusses the reported therapeutic benefits of SPMs on various diseases and their potential clinical applications.
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页数：17
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