A state-of-the-art review on solid lipid nanoparticles as a nanovaccines delivery system

In the design of vaccine generation, significant attempts have been made to produce novel vaccines and, as well, to increase the effectiveness of available vaccines versus particular diseases. Over the past few years, with nanovaccines, considerable attention has been paid to increasing vaccine effectiveness, immunization ap-proaches, and targeted transfer to attain desirable immune reactions. Solid lipid nanoparticles (SLNs) are on the front line of the quickly advancing nanotechnology field with various powerful uses in the delivery of phar-maceutical, cosmetic active, and vaccine components, from small molecules to proteins and genes with different routes of administration. SLNs have become effective delivery techniques in vaccine generation. SLNs-based vaccines can increase site-specific transfer, antigen presentation, and triggering of innate immune reaction, strong T cell reaction, and harmlessness against infectious diseases, cancers, autoimmune diseases, and neuro-degeneration. The present review will briefly explain the characteristics of SLNs and explore the other prepa-ration methods and routes of administration, focusing on SLNs as a delivery system of the different vaccines.