Transcriptomic Heterogeneity in High-risk Prostate Cancer and Implications for Extraprostatic Disease at Presentation on Prostate-specific Membrane Antigen Positron Emission Tomography

被引：2

作者：

Smith, Clayton P.

Proudfoot, James A. ^{[1
]}

Boutros, Paul C. ^{[2
,3
]}

Reiter, Robert E. ^{[3
]}

Valle, Luca

Rettig, Matthew B. ^{[3
,4
]}

Nickols, Nicholas G.

Feng, Felix Y. ^{[5
]}

Nguyen, Paul L. ^{[6
]}

Nagar, Himanshu ^{[7
]}

Spratt, Daniel E. ^{[8
]}

Attard, Gert ^{[9
]}

Weiner, Adam ^{[3
]}

Weidhaas, Joanne B.

Calais, Jeremie ^{[10
]}

Ma, T. Martin

Davicioni, Elai ^{[1
]}

Xiang, Michael

Kishan, Amar U. ^{[3
,11
]}

机构：

[1] Univ Calif Los Angeles, Dept Radiat Oncol, Los Angeles, CA USA

[2] Veracyte Inc, South San Francisco, CA USA

[3] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Dept Urol, Los Angeles, CA USA

[5] Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA USA

[6] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA USA

[7] Harvard Med Sch, Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA USA

[8] Weill Cornell Med, Dept Radiat Oncol, New York, NY USA

[9] Case Western Reserve Univ, Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Sch Med, Cleveland, OH USA

[10] UCL, Canc Inst, London, England

[11] Univ Calif Los Angeles, Depart Radiat Oncol, 200 Med Plaza Driveway, Los Angeles, CA 90095 USA

来源：

EUROPEAN UROLOGY ONCOLOGY | 2023年 / 6卷 / 02期

关键词：

Decipher score; High-risk prostate cancer; Prostate-specific membrane  antigen; Positron emission tomography; Computed tomography;

D O I：

10.1016/j.euo.2023.02.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) has greater specificity and sensitivity for detection of extraprostatic prostate cancer (PCa) at presentation than conventional imaging. Although the long-term clinical significance of acting on these findings is unknown, it has been shown that the risk of upstaging is prognostic for long-term outcomes in men with high-risk (HR) or very high-risk (VHR) PCa. We evaluated the association between the risk of upstaging on PSMA PET and the Decipher genomic classifier score, a known prognostic biomarker in localized PCa that is being evaluated for its predictive ability to direct systemic therapy intensification. In a cohort of 4625 patients with HR or VHR PCa, the risk of upstaging on PSMA PET was sig-nificantly correlated with the Decipher score (p < 0.001). These results should be seen as hypothesis-generating and warrant further studies on the causal pathways linking PSMA findings, Decipher scores, extraprostatic disease, and long-term clinical outcomes. Patient summary: We found significant correlation between the risk of having prostate cancer outside the prostate gland on a sensitive scan (based on prostate-specific mem-brane antigen [PSMA]) at initial staging and the Decipher genetic score. The results war-rant further studies on the causal pathways between PSMA scan findings, Decipher scores, disease outside the prostate, and long-term outcomes. (c) 2023 European Association of Urology. Published by Elsevier B.V. All rights reserved.

引用

页码：224 / 227

页数：4