Pre-clinical models to define correlates of protection for SARS-CoV-2

被引：4

作者：

Brady, Caolann ^{[1
,2
]}

Tipton, Tom ^{[1
,2
]}

Longet, Stephanie ^{[1
,2
,3
]}

Carroll, Miles W. ^{[1
,2
]}

机构：

[1] Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England

[2] Univ Oxford, Pandem Sci Inst, Oxford, England

[3] Claude Bernard Lyon 1 Univ, Int Ctr Infectiol Res CIRI, Team GIMAP, Inserm,U1111,CNRS,UMR530, St Etienne, France

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

animal models; SARS-CoV-2; vaccines; immunity; correlates of protection (CoP); ANTIBODY; VACCINE; INFECTION;

D O I：

10.3389/fimmu.2023.1166664

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A defined immune profile that predicts protection against a pathogen-of-interest, is referred to as a correlate of protection (CoP). A validated SARS-CoV-2 CoP has yet to be defined, however considerable insights have been provided by pre-clinical vaccine and animal rechallenge studies which have fewer associated limitations than equivalent studies in human vaccinees or convalescents, respectively. This literature review focuses on the advantages of the use of animal models for the definition of CoPs, with particular attention on their application in the search for SARS-CoV-2 CoPs. We address the conditions and interventions required for the identification and validation of a CoP, which are often only made possible with the use of appropriate in vivo models.

引用

页数：19

共 114 条

[1] COVID-19 Research: Lessons from Non-Human Primate Models [J].

Albrecht, Laure ;

Bishop, Elodie ;

Jay, Basile ;

Lafoux, Blaise ;

Minoves, Marie ;

Passaes, Caroline .

VACCINES, 2021, 9 (08)

[2] Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting TRM cells [J].

Allen, Aideen C. ;

Wilk, Mieszko M. ;

Misiak, Alicja ;

Borkner, Lisa ;

Murphy, Dearbhla ;

Mills, Kingston H. G. .

MUCOSAL IMMUNOLOGY, 2018, 11 (06) :1763-1776

[3] A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection [J].

Alsoussi, Wafaa B. ;

Turner, Jackson S. ;

Case, James B. ;

Zhao, Haiyan ;

Schmitz, Aaron J. ;

Zhou, Julian Q. ;

Chen, Rita E. ;

Lei, Tingting ;

Rizk, Amena A. ;

McIntire, Katherine M. ;

Winkler, Emma S. ;

Fox, Julie M. ;

Kafai, Natasha M. ;

Thackray, Larissa B. ;

Hassan, Ahmed O. ;

Amanat, Fatima ;

Krammer, Florian ;

Watson, Corey T. ;

Kleinstein, Steven H. ;

Fremont, Daved H. ;

Diamond, Michael S. ;

Ellebedy, Ali H. .

JOURNAL OF IMMUNOLOGY, 2020, 205 (04) :915-922

[4] Immunogenicity of SCB-2019 Coronavirus Disease 2019 Vaccine Compared With 4 Approved Vaccines [J].

Ambrosino, Donna ;

Han, Htay Htay ;

Hu, Branda ;

Liang, Joshua ;

Clemens, Ralf ;

Johnson, Marina ;

Siber, George ;

Goldblatt, David .

JOURNAL OF INFECTIOUS DISEASES, 2022, 225 (02) :327-331

[5]

[Anonymous], 2020, WHO DIR GEN OP REM M

[6] Adjuvanting a subunit COVID-19 vaccine to induce protective immunity [J].

Arunachalam, Prabhu S. ;

Walls, Alexandra C. ;

Golden, Nadia ;

Atyeo, Caroline ;

Fischinger, Stephanie ;

Li, Chunfeng ;

Aye, Pyone ;

Navarro, Mary Jane ;

Lai, Lilin ;

Edara, Venkata Viswanadh ;

Roltgen, Katharina ;

Rogers, Kenneth ;

Shirreff, Lisa ;

Ferrell, Douglas E. ;

Wrenn, Samuel ;

Pettie, Deleah ;

Kraft, John C. ;

Miranda, Marcos C. ;

Kepl, Elizabeth ;

Sydeman, Claire ;

Brunette, Natalie ;

Murphy, Michael ;

Fiala, Brooke ;

Carter, Lauren ;

White, Alexander G. ;

Trisal, Meera ;

Hsieh, Ching-Lin ;

Russell-Lodrigue, Kasi ;

Monjure, Christopher ;

Dufour, Jason ;

Spencer, Skye ;

Doyle-Meyers, Lara ;

Bohm, Rudolph P. ;

Maness, Nicholas J. ;

Roy, Chad ;

Plante, Jessica A. ;

Plante, Kenneth S. ;

Zhu, Alex ;

Gorman, Matthew J. ;

Shin, Sally ;

Shen, Xiaoying ;

Fontenot, Jane ;

Gupta, Shakti ;

O'Hagan, Derek T. ;

Van Der Most, Robbert ;

Rappuoli, Rino ;

Coffman, Robert L. ;

Novack, David ;

McLellan, Jason S. ;

Subramaniam, Shankar .

NATURE, 2021, 594 (7862) :253-+

[7] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[8] Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses [J].

Barrett, Jordan R. ;

Belij-Rammerstorfer, Sandra ;

Dold, Christina ;

Ewer, Katie J. ;

Folegatti, Pedro M. ;

Gilbride, Ciaran ;

Halkerston, Rachel ;

Hill, Jennifer ;

Jenkin, Daniel ;

Stockdale, Lisa ;

Verheul, Marije K. ;

Aley, Parvinder K. ;

Angus, Brian ;

Bellamy, Duncan ;

Berrie, Eleanor ;

Bibi, Sagida ;

Bittaye, Mustapha ;

Carroll, Miles W. ;

Cavell, Breeze ;

Clutterbuck, Elizabeth A. ;

Edwards, Nick ;

Flaxman, Amy ;

Fuskova, Michelle ;

Gorringe, Andrew ;

Hallis, Bassam ;

Kerridge, Simon ;

Lawrie, Alison M. ;

Linder, Aline ;

Liu, Xinxue ;

Madhavan, Meera ;

Makinson, Rebecca ;

Mellors, Jack ;

Minassian, Angela ;

Moore, Maria ;

Mujadidi, Yama ;

Plested, Emma ;

Poulton, Ian ;

Ramasamy, Maheshi N. ;

Robinson, Hannah ;

Rollier, Christine S. ;

Song, Rinn ;

Snape, Matthew D. ;

Tarrant, Richard ;

Taylor, Stephen ;

Thomas, Kelly M. ;

Voysey, Merryn ;

Watson, Marion E. E. ;

Wright, Daniel ;

Douglas, Alexander D. ;

Green, Catherine M. .

NATURE MEDICINE, 2021, 27 (02) :279-+

[9] REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters [J].

Baum, Alina ;

Ajithdoss, Dharani ;

Copin, Richard ;

Zhou, Anbo ;

Lanza, Kathryn ;

Negron, Nicole ;

Ni, Min ;

Wei, Yi ;

Mohammadi, Kusha ;

Musser, Bret ;

Atwal, Gurinder S. ;

Oyejide, Adelekan ;

Goez-Gazi, Yenny ;

Dutton, John ;

Clemmons, Elizabeth ;

Staples, Hilary M. ;

Bartley, Carmen ;

Klaffke, Benjamin ;

Alfson, Kendra ;

Gazi, Michal ;

Gonzalez, Olga ;

Dick, Edward, Jr. ;

Carrion, Ricardo, Jr. ;

Pessaint, Laurent ;

Porto, Maciel ;

Cook, Anthony ;

Brown, Renita ;

Ali, Vaneesha ;

Greenhouse, Jack ;

Taylor, Tammy ;

Andersen, Hanne ;

Lewis, Mark G. ;

Stahl, Neil ;

Murphy, Andrew J. ;

Yancopoulos, George D. ;

Kyratsous, Christos A. .

SCIENCE, 2020, 370 (6520) :1110-+

[10] EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop [J].

Beguelin, Wendy ;

Rivas, Martin A. ;

Fernandez, Maria T. Calvo ;

Teater, Matt ;

Purwada, Alberto ;

Redmond, David ;

Shen, Hao ;

Challman, Matt F. ;

Elemento, Olivier ;

Singh, Ankur ;

Melnick, Ari M. .

NATURE COMMUNICATIONS, 2017, 8

← 1 2 3 4 5 6 7 8 9 10 →