Targeting the nucleolus as a therapeutic strategy in human disease

被引：29

作者：

Corman, Alba ^{[1
]}

Sirozh, Oleksandra ^{[2
]}

Lafarga, Vanesa ^{[2
]}

Fernandez-Capetillo, Oscar ^{[1
,2
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, Div Genome Biol, Sci Life Lab, Stockholm, Sweden

[2] Spanish Natl Canc Res Ctr CNIO, Genom Instabil Grp, Madrid 28029, Spain

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2023年 / 48卷 / 03期

基金：

瑞典研究理事会;

关键词：

RNA-POLYMERASE-I; RIBOSOME BIOGENESIS; CANCER; TRANSCRIPTION; EXPRESSION; CELLS; ACTIVATION; INHIBITION; CISPLATIN; LONGEVITY;

D O I：

10.1016/j.tibs.2022.09.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nucleolus is the site of ribosome biogenesis, one of the most resource-intensive processes in eukaryotic cells. Accordingly, nucleolar morphology and activity are highly responsive to growth signaling and nucleolar insults which are collectively included in the actively evolving concept of nucleolar stress. Importantly, nucleolar alterations are a prominent feature of multiple human pathologies, including cancer and neurodegeneration, as well as being associated with aging. The past decades have seen numerous attempts to isolate compounds targeting different facets of nucleolar activity. We provide an overview of therapeutic opportunities for targeting nucleoli in different pathologies and currently available therapies.

引用

页码：274 / 287

页数：14

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