Prevention and Treatment Strategies for Respiratory Syncytial Virus (RSV)

被引：59

作者：

Gatt, Dvir ^{[1
]}

Martin, Isaac ^{[1
]}

AlFouzan, Rawan ^{[1
]}

Moraes, Theo J. J. ^{[1
,2
]}

机构：

[1] Hosp Sick Children, Dept Pediat, Div Resp Med, Toronto, ON M5G 1X8, Canada

[2] Hosp Sick Children, Program Translat Med, Toronto, ON M5G 1X8, Canada

来源：

PATHOGENS | 2023年 / 12卷 / 02期

关键词：

respiratory syncytial virus; antiviral; vaccine; bronchiolitis; monoclonal antibodies; RECOMBINANT HUMAN DEOXYRIBONUCLEASE; NEBULIZED HYPERTONIC SALINE; HOSPITALIZED INFANTS; AEROSOLIZED RIBAVIRIN; NATURAL REINFECTION; CONTROLLED-TRIAL; TRACT INFECTION; BRONCHIOLITIS; CHILDREN; VACCINE;

D O I：

10.3390/pathogens12020154

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease, especially in young children. Despite its global impact on healthcare, related to its high prevalence and its association with significant morbidity, the current therapy is still mostly supportive. Moreover, while more than 50 years have passed since the first trial of an RSV vaccine (which unfortunately caused enhanced RSV disease), no vaccine has been approved for RSV prevention. In the last two decades, our understanding of the pathogenesis and immunopathology of RSV have continued to evolve, leading to significant advancements in RSV prevention strategies. These include both the development of new potential vaccines and the successful implementation of passive immunization, which, together, will provide coverage from infancy to old age. In this review, we provide an update of the current treatment options for acute disease (RSV-specific and -non-specific) and different therapeutic approaches focusing on RSV prevention.

引用

页数：17

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