BRAIN INSULIN SIGNALING AND COGNITION: POSSIBLE LINKS

被引：0

作者：

Yaribeygi, Habib ^{[1
]}

Maleki, Mina ^{[2
]}

Butler, Alexandra E. ^{[3
]}

Jamialahmadi, Tannaz ^{[4
,5
]}

Sahebkar, Amirhossein ^{[4
,6
,7
]}

机构：

[1] Semnan Univ Med Sci, Res Ctr Physiol, Semnan, Iran

[2] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, Tehran, Iran

[3] Royal Coll Surg Ireland, Res Dept, POB 15503, Adliya, Bahrain

[4] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran

[5] Mashhad Univ Med Sci, Surg Oncol Res Ctr, Mashhad, Iran

[6] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran

[7] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran

来源：

EXCLI JOURNAL | 2023年 / 22卷

关键词：

Diabetes mellitus; brain insulin signaling; cognition; senile plaque; mitochondria; HIPPOCAMPAL SYNAPTIC PLASTICITY; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; RESISTANCE; RECEPTOR; IMPAIRMENT; NEURODEGENERATION; PHOSPHORYLATION; NEUROGENESIS; INDIVIDUALS;

D O I：

10.17179/excli2023-5841

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Poor cognitive ability is a consequence of a wide variety of neurobehavioral disorders and is a growing health problem, especially among the elderly and patients with diabetes. The precise underlying cause of this complica-tion is not well-defined. However, recent studies have highlighted the possible role of insulin hormone signaling in brain tissue. Insulin is a metabolic peptide integral to whole body energy homeostasis; it does, however, have extrametabolic impacts, such as upon neuronal circuits. Therefore, it has been suggested that insulin signaling may modify cognitive ability by yet unknown pathways. In the current review, we discuss the cognitive role of brain insulin signaling and consider the possible links between brain insulin signaling and cognitive ability.

引用

页码：237 / 249

页数：13

共 100 条

[1] The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses [J].