Sex and pubertal influences on the neurodevelopmental underpinnings of schizophrenia: A case for longitudinal research on adolescents

被引：9

作者：

Barendse, M. E. A. ^{[1
]}

Lara, G. A. ^{[1
]}

Guyer, A. E. ^{[2
,3
]}

Swartz, J. R. ^{[3
]}

Taylor, S. L. ^{[4
]}

Shirtcliff, E. A. ^{[5
]}

Lamb, S. T. ^{[1
]}

Miller, C. ^{[1
]}

Ng, J. ^{[1
]}

Yu, G. ^{[1
]}

Tully, L. M. ^{[1
,6
]}

机构：

[1] Univ Calif Davis, Dept Psychiat & Behav Sci, Davis, CA USA

[2] Univ Calif Davis, Dept Human Ecol, Davis, CA USA

[3] Univ Calif Davis, Ctr Mind & Brain, Davis, CA USA

[4] Univ Calif Davis, Dept Publ Hlth Sci, Div Biostat, Davis, CA USA

[5] Iowa State Univ, Human Dev & Family Studies, Ames, IA USA

[6] Univ Calif Davis, Dept Psychiat & Behav Sci, 2248 Stockton Blvd, Sacramento, CA 95817 USA

来源：

SCHIZOPHRENIA RESEARCH | 2023年 / 252卷

关键词：

Hormones; Sex; -specific; Pathophysiology; Psychosis; MRI; REWARD PREDICTION; BRAIN-DEVELOPMENT; NEURAL RESPONSE; 1ST EPISODE; HIGH-RISK; SCHIZOAFFECTIVE DISORDER; EMOTION REGULATION; SYMPTOM SEVERITY; PSYCHOSIS; AGE;

D O I：

10.1016/j.schres.2022.12.011

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Sex is a significant source of heterogeneity in schizophrenia, with more negative symptoms in males and more affective symptoms and internalizing comorbidity in females. In this narrative review, we argue that there are likely sex differences in the pathophysiological mechanisms of schizophrenia-spectrum disorders (SZ) that originate during puberty and relate to the sex-specific impacts of pubertal maturation on brain development. Pubertal maturation might also trigger underlying (genetic or other) vulnerabilities in at-risk individuals, influencing brain development trajectories that contribute to the emergence of SZ. This review is the first to integrate links between pubertal development and neural development with cognitive neuroscience research in SZ to form and evaluate these hypotheses, with a focus on the frontal-striatal and frontal-limbic networks and their hypothesized contribution to negative and mood symptoms respectively. To test these hypotheses, longitudinal research with human adolescents is needed that examines the role of sex and pubertal development using large cohorts or high risk samples. We provide recommendations for such studies, which will integrate the fields of psychiatry, developmental cognitive neuroscience, and developmental endocrinology towards a more nuanced understanding of the role of pubertal factors in the hypothesized sex-specific pathophysiological mechanisms of schizophrenia.

引用

页码：231 / 241

页数：11