Mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine

被引：21

作者：

Liao, Yanfang ^{[1
]}

Wang, Xue ^{[1
]}

Huang, Liting ^{[1
]}

Qian, Hu ^{[2
]}

Liu, Wei ^{[3
,4
]}

机构：

[1] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou, Guangdong, Peoples R China

[2] Foshan 1 Hosp, Dept Breast Canc Oncol, Foshan, Peoples R China

[3] Guangzhou Univ Chinese Med, Clin Med Coll 1, Guangzhou, Guangdong, Peoples R China

[4] Univ Chinese Med, Affiliated Hosp Guangzhou 1, Integrat Canc Ctr, Guangzhou, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

pyroptosis; neurodegenerative diseases; traditional Chinese medicine; neuroinflammation; neuroprotection; NLRP3 INFLAMMASOME ACTIVATION; MULTIPLE-SCLEROSIS; MOUSE MODEL; MOLECULAR-MECHANISMS; ALZHEIMERS-DISEASE; IMMUNE RECEPTORS; GASDERMIN D; CELL-DEATH; IL-1-BETA; GSDMD;

D O I：

10.3389/fphar.2023.1122104

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neurodegenerative diseases (NDs) are disorders characterized by degenerative degeneration of neurons and loss of their function. NDs have a complicated pathophysiology, of which neuroinflammation and neuronal death are significant factors. The inflammatory process known as pyroptosis ( "fiery death ") is caused by a family of pore-forming proteins called Gasdermins (GSDMs), which appears downstream from the activation of the inflammasome. Clear evidence of enhanced pyroptosis-related proteins activity in common NDs has coincided with abnormal aggregation of pathological proteins (such as A beta, tau, alpha-synuclein et al.), making pyroptosis an attractive direction for the recent study of NDs. The purpose of this review is to provide an overview of the molecular mechanisms driving pyroptosis, the mechanistic links between pyroptosis and NDs, and emerging therapeutic strategies in Traditional Chinese Medicine (TCM) to inhibit pyroptosis for the treatment of NDs.

引用

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