Spleen stiffness in patients with chronic liver disease evaluated by 2-D shear wave elastography with ultrasound multiparametric imaging

被引：7

作者：

Hirooka, Masashi ^{[1
]}

Koizumi, Yohei ^{[1
]}

Nakamura, Yoshiko ^{[1
]}

Yano, Ryo ^{[1
]}

Okazaki, Yuki ^{[1
]}

Sunago, Koutarou ^{[1
]}

Imai, Yusuke ^{[1
]}

Watanabe, Takao ^{[1
]}

Yoshida, Osamu ^{[1
]}

Tokumoto, Yoshio ^{[1
]}

Abe, Masanori ^{[1
]}

Hiasa, Yoichi ^{[1
]}

机构：

[1] Ehime Univ, Dept Gastroenterol & Metabol, Grad Sch Med, Toon, Ehime 7910295, Japan

来源：

HEPATOLOGY RESEARCH | 2023年 / 53卷 / 02期

基金：

日本学术振兴会;

关键词：

portal hypertension; shear wave dispersion; shear wave speed; spleen; viscosity; PORTAL-HYPERTENSION; ESOPHAGEAL-VARICES; RISK;

D O I：

10.1111/hepr.13841

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background The novel 2-D shear wave elastography (2D-SWE) can measure two ultrasound parameters: shear wave dispersion (SWD) and shear wave speed (SWS). We investigated the ability of 2D-SWE in measuring spleen stiffness using ultrasound multiparametric imaging. Methods This cross-sectional study included patients with chronic liver disease who underwent esophagogastroduodenoscopy and ultrasonographic examinations of the spleen between September 2018 and December 2021. In total, 157 patients were enrolled in this study: 81 and 67 patients were included in the pilot set for hepatic venous pressure gradient (HVPG) measurements and validation cohort without HVPG measurements, respectively. To confirm reproducibility between the two examiners, an additional 30 patients were enrolled. Results The Bland-Altman plots revealed no significant bias in the SWD as measured by two examiners. The splenic SWS (r = 0.752) and SWD (r = 0.444) were correlated with the HVPG. Regarding high-risk varices, as per the Youden index, the cut-off value for splenic SWS was 3.30 m/s, with a sensitivity of 85.7%, specificity of 92.5%, positive predictive value of 85.7%, and negative predictive value of 92.4% in the pilot set. In the validation set, good diagnostic performance by the splenic SWS was observed. However, SWD did not perform as well as SWS. Conclusions The splenic SWS, measured using ultrasound multiparametric imaging, was closely correlated with the HVPG. Thus, SWS is a useful predictive marker for high-risk varices.

引用

页码：93 / 103

页数：11

共 28 条

[11] Measurement of multiple spleen lengths is not necessary for non-invasive prediction of high-risk esophagogastric varices [J].