Niche-specific control of tissue function by regulatory T cells-Current challenges and for metabolic disease

被引：7

作者：

Becker, Maike ^{[1
,2
]}

Dirschl, Sandra M. ^{[1
,2
]}

Scherm, Martin G. ^{[1
,2
]}

Serr, Isabelle ^{[1
,2
]}

Daniel, Carolin ^{[1
,2
,3
]}

机构：

[1] Helmholtz Zentrum Munchen, Helmholtz Diabet Ctr, Res Div Type 1 Diabet Immunol, D-80939 Munich, Germany

[2] Deutsch Zentrum Diabet Forschung DZD, D-85764 Munich, Germany

[3] Ludwig Maximilians Univ Munchen, Dept Med 4, Div Clin Pharmacol, D-80336 Munich, Germany

来源：

CELL METABOLISM | 2024年 / 36卷 / 02期

关键词：

VISCERAL ADIPOSE-TISSUE; SKELETAL-MUSCLE; REG CELLS; INSULIN-RESISTANCE; PPAR-GAMMA; ACCUMULATION; POPULATION; COLITIS; GENE; SUPPRESSION;

D O I：

10.1016/j.cmet.2023.12.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tissue regulatory T cells (Tregs) exert pivotal functions in both immune and metabolic regulation, maintaining local tissue homeostasis, integrity, and function. Accordingly, Tregs play a crucial role in controlling obesity-induced inflammation and supporting efficient muscle function and repair. Depending on the tissue context, Tregs are characterized by unique transcriptomes, growth, and survival factors and T cell receptor (TCR) repertoires. This functional specialization offers the potential to selectively target context-specific Treg populations, tailoring therapeutic strategies to specific niches, thereby minimizing potential side effects. Here, we discuss challenges and perspectives for niche-specific Treg targeting, which holds promise for highly efficient and precise medical interventions to combat metabolic disease.

引用

页码：229 / 239

页数：11

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