Syndromic and Monogenic Obesity: New Opportunities Due to Genetic-Based Pharmacological Treatment

被引:3
作者
Kalinderi, Kallirhoe [1 ]
Goula, Vasiliki [2 ]
Sapountzi, Evdoxia [3 ]
Tsinopoulou, Vasiliki Rengina [3 ]
Fidani, Liana [1 ,3 ]
机构
[1] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Lab Med Biol Genet, Thessaloniki 54124, Greece
[2] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Thessaloniki 54124, Greece
[3] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Fac Hlth Sci, Sch Med,Dept Pediat 2, Thessaloniki 54636, Greece
来源
CHILDREN-BASEL | 2024年 / 11卷 / 02期
关键词
genetic obesity; monogenic obesity; syndromic obesity; Prader-Willi syndrome; Bardet-Biedl syndrome; melanocortin; 4; receptor; congenital leptin deficiency; setmelanotide; GLP-1 R agonists; semaglutide; PRADER-WILLI-SYNDROME; GLP-1 RECEPTOR AGONIST; BARDET-BIEDL SYNDROME; MC4R AGONIST; MENTAL DEFICIENCY; WEIGHT-LOSS; LEPTIN; MUTATIONS; SETMELANOTIDE; INDIVIDUALS;
D O I
10.3390/children11020153
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Obesity is a significant health problem with a continuously increasing prevalence among children and adolescents that has become a modern pandemic during the last decades. Nowadays, the genetic contribution to obesity is well-established. For this narrative review article, we searched PubMed and Scopus databases for peer-reviewed research, review articles, and meta-analyses regarding the genetics of obesity and current pharmacological treatment, published in the English language with no time restrictions. We also screened the references of the selected articles for possible additional articles in order to include most of the key recent evidence. Our research was conducted between December 2022 and December 2023. We used the terms "obesity", "genetics", "monogenic", "syndromic", "drugs", "autosomal dominant", "autosomal recessive", "leptin-melanocortin pathway", and "children" in different combinations. Recognizing the genetic background in obesity can enhance the effectiveness of treatment. During the last years, intense research in the field of obesity treatment has increased the number of available drugs. This review analyzes the main categories of syndromic and monogenic obesity discussing current data on genetic-based pharmacological treatment of genetic obesity and highlighting the necessity that cases of genetic obesity should follow specific, pharmacological treatment based on their genetic background.
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页数:14
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共 105 条
[61]   Update on the Genetics of Bardet-Biedl Syndrome [J].
M'hamdi, O. ;
Ouertani, I. ;
Chaabouni-Bouhamed, H. .
MOLECULAR SYNDROMOLOGY, 2014, 5 (02) :51-56
[62]   LMO2 gene deletions significantly worsen the prognosis of Wilms' tumor development in patients with WAGR syndrome [J].
Marakhonov, Andrey, V ;
Vasilyeva, Tatyana A. ;
Voskresenskaya, Anna A. ;
Sukhanova, Natella, V ;
Kadyshev, Vitaly V. ;
Kutsev, Sergey, I ;
Zinchenko, Rena A. .
HUMAN MOLECULAR GENETICS, 2019, 28 (19) :3323-3326
[63]   Setmelanotide: First Approval [J].
Markham, Anthony .
DRUGS, 2021, 81 (03) :397-403
[64]   Clinical utility gene card for: Alstrom Syndrome update 2013 [J].
Marshall, Jan D. ;
Maffei, Pietro ;
Beck, Sebastian ;
Barrett, Timothy G. ;
Paisey, Richard ;
Naggert, Juergen K. .
EUROPEAN JOURNAL OF HUMAN GENETICS, 2013, 21 (11) :1324-4
[65]   Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial [J].
McCandless, Shawn E. ;
Yanovski, Jack A. ;
Miller, Jennifer ;
Fu, Cary ;
Bird, Lynne M. ;
Salehi, Parisa ;
Chan, Christine L. ;
Stafford, Diane ;
Abuzzahab, M. Jennifer ;
Viskochil, David ;
Barlow, Sarah E. ;
Angulo, Moris ;
Myers, Susan E. ;
Whitman, Barbara Y. ;
Styne, Dennis ;
Roof, Elizabeth ;
Dykens, Elisabeth M. ;
Scheimann, Ann O. ;
Malloy, Jaret ;
Zhuang, Dongliang ;
Taylor, Kristin ;
Hughes, Thomas E. ;
Kim, Dennis D. ;
Butler, Merlin G. .
DIABETES OBESITY & METABOLISM, 2017, 19 (12) :1751-1761
[66]   Small extracellular vesicle targeting of hypothalamic AMPKα1 promotes weight loss in leptin receptor deficient mice [J].
Milbank, Edward ;
Dragano, Nathalia ;
Vidal-Gomez, Xavi ;
Rivas-Limeres, Veronica ;
Garrido-Gil, Pablo ;
Wertheimer, Mireille ;
Recoquillon, Sylvain ;
Pata, Maria P. ;
Labandeira-Garcia, Jose Luis ;
Dieguez, Carlos ;
Nogueiras, Ruben ;
Martinez, M. Carmen ;
Andriantsitohaina, Ramaroson ;
Lopez, Miguel .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2023, 139
[67]   Diazoxide Choline Extended-Release Tablet in People With Prader-Willi Syndrome: A Double-Blind, Placebo-Controlled Trial [J].
Miller, Jennifer L. ;
Gevers, Evelien ;
Bridges, Nicola ;
Yanovski, Jack A. ;
Salehi, Parisa ;
Obrynba, Kathryn S. ;
Felner, Eric, I ;
Bird, Lynne M. ;
Shoemaker, Ashley H. ;
Angulo, Moris ;
Butler, Merlin G. ;
Stevenson, David ;
Abuzzahab, Jennifer ;
Barrett, Timothy ;
Lah, Melissa ;
Littlejohn, Elizabeth ;
Mathew, Verghese ;
Cowen, Neil M. ;
Bhatnagar, Anish .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2023, 108 (07) :1676-1685
[68]   The effects of glucagon-like peptide (GLP)-1 receptor agonists on weight and glycaemic control in Prader-Willi syndrome: A systematic review [J].
Ng, Nicholas Beng Hui ;
Low, Yue Wey ;
Rajgor, Dimple Dayaram ;
Low, Jia Ming ;
Lim, Yvonne Yijuan ;
Loke, Kah Yin ;
Lee, Yung Seng .
CLINICAL ENDOCRINOLOGY, 2022, 96 (02) :144-154
[69]   Intensive management of obesity in people with Prader-Willi syndrome [J].
Nolan, Brendan J. ;
Proietto, Joseph ;
Sumithran, Priya .
ENDOCRINE, 2022, 77 (01) :57-62
[70]   Trends in Obesity Prevalence Among Children and Adolescents in the United States, 1988-1994 Through 2013-2014 [J].
Ogden, Cynthia L. ;
Carroll, Margaret D. ;
Lawman, Hannah G. ;
Fryar, Cheryl D. ;
Kruszon-Moran, Deanna ;
Kit, Brian K. ;
Flegal, Katherine M. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 315 (21) :2292-2299