The versatile nature of indole containing Schiff bases: An Overview

Carbonyl compounds such as aldehydes or ketones condense with amines to form Schiff bases. The synthesis of Schiff bases containing indole rings yields a broad spectrum of complexes. The paper covers the chemistry of Schiff bases, including the approaches used to create indole Schiff bases and the corresponding metal complexes, ranging from the most conventional to novel approaches that also incorporate green technology. For instance, the article explains the microwave method of indole Schiff base synthesis, which is a quick and effective procedure. Additionally, it presents an innovative synthetic approach known as "direct fusion," which eliminates the need for solvents and reduces the long-term heating requirement by following environmentally conscious and sustainable practices. These indole Schiff bases are incredibly versatile and have attracted much interest in the field of biomedicine. They are helpful in various fields, including those involving antibacterial treatments, cancer therapy, anti-inflammatory medications, antioxidants, and even issues relating to obesity. In addition to their importance for biomedicine, these compounds have beneficial industrial uses as chemosensors, corrosion inhibitors, and heterogeneous catalysts. The effect of chemical alterations made by suitable substituents on the characteristics of Schiff bases and their metal complexes is one of the major revelations made in this article. These complexes frequently display better qualities than their parent Schiff bases, which broadens the range of possible applications for them.