TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling

被引：1

作者：

Wang, Ming-Dian ^{[1
,2
,3
,4
]}

Li, Hui-Ting ^{[2
,3
,4
,5
]}

Peng, Li-Xia ^{[2
,3
,4
]}

Mei, Yan ^{[6
]}

Zheng, Li-Sheng ^{[6
]}

Li, Chang-Zhi ^{[7
]}

Meng, Dong-Fang ^{[8
]}

Lang, Yan-Hong ^{[2
,3
,4
]}

Xu, Liang ^{[9
]}

Peng, Xing-Si ^{[10
]}

Liu, Zhi-Jie ^{[2
,3
,4
,11
]}

Xie, De-Huan ^{[2
,3
,4
]}

Guo, Ling-Ling ^{[2
,3
,4
]}

Ma, Mao-Guang ^{[12
]}

Ding, Liu-Yan ^{[2
,3
,4
]}

Huang, Bi-Jun ^{[2
,3
,4
]}

Cao, Yun ^{[1
,2
,3
,4
]}

Qian, Chao-Nan ^{[2
,3
,4
,13
]}

机构：

[1] Sun Yat Sen Univ, Canc Ctr, Dept Pathol, Guangzhou 510060, Peoples R China

[2] Sun Yat Sen Univ, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China

[3] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Canc Ctr, Guangzhou 510060, Peoples R China

[4] Sun Yat Sen Univ, Guangdong Key Lab Nasopharyngeal Carcinoma Diag &, Canc Ctr, Guangzhou 510060, Peoples R China

[5] Sun Yat Sen Univ, Dept Anesthesiol, Canc Ctr, Guangzhou 510060, Peoples R China

[6] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Pathol, Guangzhou 510080, Peoples R China

[7] Pingdingshan Univ, Med Sch, Pingdingshan 467021, Henan, Peoples R China

[8] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250117, Peoples R China

[9] Sun Yat Sen Univ, Affiliated Hosp 6, Inst Gastroenterol, Guangzhou 510655, Peoples R China

[10] Guangzhou Med Univ, Dept Radiat Oncol, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China

[11] Southern Med Univ, Affiliated Dongguan Hosp, Dongguan Peoples Hosp, Dept Radiotherapy, Dongguan, Guangdong, Peoples R China

[12] Fudan Univ, Shanghai Canc Ctr, Dept Colorectal Surg, Shanghai 200032, Peoples R China

[13] Guangzhou Concord Canc Ctr, Guangzhou 510060, Peoples R China

来源：

CANCER GENE THERAPY | 2024年 / 31卷 / 03期

基金：

中国国家自然科学基金;

关键词：

KAPPA-B; PROMOTES METASTASIS; CANCER; PROTEINS; ACTIVATION;

D O I：

10.1038/s41417-023-00716-w

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nasopharyngeal carcinoma (NPC) originates in the epithelial cells of the nasopharynx and is a common malignant tumor in southern China and Southeast Asia. Metastasis of NPC remains the main cause of death for NPC patients even though the tumor is sensitive to radiotherapy and chemotherapy. Here, we found that the transmembrane protein tetraspanin1 (TSPAN1) potently inhibited the in vitro migration and invasion, as well as, the in vivo metastasis of NPC cells via interacting with the IKBB protein. In addition, TSPAN1 was essential in preventing the overactivation of the NF-kB pathway in TSPAN1 overexpressing NPC cells. Furthermore, reduced TSPAN1 expression was associated with NPC metastasis and the poor prognosis of NPC patients. These results uncovered the suppressive role of TSPAN1 against NF-kB signaling in NPC cells for preventing NPC metastasis. Its therapeutic value warrants further investigation.

引用

页码：454 / 463

页数：10

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