Interferon-γ sensing by epithelial cells tames gut inflammation

被引：2
|
作者：
Pabst, Oliver [1 ]
Cerovic, Vuk [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Mol Med, Aachen, Germany
来源：
NATURE IMMUNOLOGY | 2024年 / 25卷 / 01期
关键词：
COLITIS;
D O I：
10.1038/s41590-023-01705-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Epithelial cells, macrophages and T cells are linked in a previously unknown regulatory circuit. Sensing of interferon-gamma triggers antigen presentation by colonic epithelial cells, enabling T cells to lower extracellular ATP levels and reduce inflammation.
引用
收藏
页码：9 / 10
页数：2
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