AN ECO-FRIENDLY ULTRASOUND-ASSISTED ONE-POT THREE-COMPONENT SYNTHESIS OF 1,4-DIHYDROPYRIMIDO [1,2-A]BENZIMIDAZOLE DERIVATIVES CATALYZED BY MAGHNITE-H+

被引:0
作者
Ben Messaoud, Hadda [1 ]
Benlahreche, Boumadiene [1 ,2 ]
Djemoui, Amar [1 ]
Souli, Lahcene [1 ]
Lahrech, Mokhtar Boualem [1 ]
机构
[1] Ziane Achour Univ Djelfa, Fac Exact Sci & Informat, Lab Organ Chem & Nat Subst, Djelfa, Algeria
[2] Univ Oran 1 Ahmed Ben Bella, Fac Exact & Appl Sci, Dept Chem, Lab Fine Chem, PB 1524, El Mnaouer, Algeria
来源
HETEROCYCLIC LETTERS | 2023年 / 13卷 / 03期
关键词
1,4-dihydropyrimido[1,2-a]benzimidazole; One-pot multicomponent reactions; Benzaldehyde; ketone; 2-Aminobenzimidazole; Maghnite-H+; Ultrasound irradiation; EFFICIENT; ACID; CLAY;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A simple and efficient procedure is developed for the synthesis of 1,4-dihydropyrimido[1,2a]benzimidazole derivatives (DHPBz) via one-pot multi-component reaction of an aromatic aldehydes, ketones and 2-aminobenzimidazole, with use of a proton exchanged Algerian montmorillonite clay (Maghnite-H+) as green catalyst under ultrasound irradiation. This approach has the major advantages of short reaction time, good yields, easy operation, low energy consumption, and environmental friendliness. In addition, the solid non-toxic catalyst could be removed from the reaction mixture by simple filtration and recyclable without a lack of catalytic activity. All of the products were characterized by IR and NMR spectroscopy, MS, and elemental analysis.
引用
收藏
页码:449 / 457
页数:9
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