Caffeine Administration in Piglets with Low Birthweight and Low Vitality Scores, and Its Effect on Physiological Blood Profile, Acid-Base Balance, Gas Exchange, and Infrared Thermal Response

被引：1

作者：

Villanueva-Garcia, Dina ^{[1
]}

Ghezzi, Marcelo ^{[2
]}

Mora-Medina, Patricia ^{[3
]}

Hernandez-Avalos, Ismael ^{[3
]}

Olmos-Hernandez, Adriana ^{[4
]}

Casas-Alvarado, Alejandro ^{[5
]}

Lezama-Garcia, Karina ^{[5
]}

Dominguez-Oliva, Adriana ^{[5
]}

Rodriguez-Gonzalez, Daniela ^{[5
]}

Marcet-Rius, Miriam ^{[6
]}

机构：

[1] Hosp Infantil Mexico Dr Federico Gomez, Natl Inst Hlth, Div Neonatol, Mexico City 06720, Mexico

[2] Univ Nacl Ctr Prov Buenos Aires UNCPBA, Fac Vet Sci FCV, Anim Welf Area, Univ Campus, RA-7000 Tandil, Argentina

[3] Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Cuautitlan 54714, Mexico

[4] Inst Nacl Rehabil Luis Guillermo Ibarra INR LGII, Div Biotechnol Bioterio & Expt Surg, Mexico City 14389, Mexico

[5] Univ Autonoma Metropolitana, Neurophysiol Behav & Anim Welf Assesment, DPAA, Xochimilco Campus, Mexico City 04960, Mexico

[6] Res Inst Semiochem & Appl Ethol IRSEA, Dept Anim Behav & Welf, F-84400 Apt, France

来源：

ANIMALS | 2023年 / 13卷 / 22期

关键词：

caffeine; newborn piglet; blood profile; vitality score; acid-base imbalance; COLOSTRUM INTAKE; SOWS; PERFORMANCE; CARBETOCIN; MORTALITY; BORN;

D O I：

10.3390/ani13223491

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Simple Summary Intrapartum mortality reaches high figures in piglets, and it has been seen that those born with low weight and those with low or failed vitality scores are the most prone. Caffeine is used to reduce cardiorespiratory problems in neonates, both humans and animals. For this reason, the decision was made to use different doses of caffeine in newborn piglets in this study, to define if its oral administration would help reduce this problem and what would be the optimal dose and time of administration. The following blood gas parameters were evaluated: pH, pO2, pCO2, HCO3, Ca++, glucose, and lactate, as well as superficial and rectal temperature at 1 h, 6 h, and 24 h after birth. It was concluded that the optimal dose of caffeine to improve the vitality score and reduce possible cardiorespiratory problems is 30 mg/kg orally.Abstract Intrapartum asphyxia, fetal hypoxia, and their consequences (e.g., acidosis, hypercapnia, hypoglycemia, and hypothermia) are the main factors related to physio-metabolic imbalances that increase neonatal mortality in piglets, particularly in piglets with low birthweight and low vitality scores. This study aimed to evaluate the effect of three different doses of caffeine (10, 20, and 30 mg/kg) administered orally to 480 newborn piglets with low birthweight and low vitality scores. Blood gas parameters (pH, pO2, pCO2, and HCO3-), physio-metabolic profile (Ca++, glucose, and lactate), and the thermal response assessed through infrared thermography in four thermal windows (ocular, auricular, snout, and hindlimb) and rectal temperature were evaluated during the first 24 h of life. Doses of 30 mg/kg resulted in significant differences at 24 h for all evaluated parameters, suggesting that caffeine administration improved the cardiorespiratory function and metabolic activity of piglets by reducing acidosis, restoring glycemia, and increasing surface and rectal temperature. In conclusion, caffeine at 30 mg/kg could be suggested as an appropriate dose to use in piglets with low birthweight and low vitality scores. Future research might need to study the presentation of adverse effects due to higher caffeine concentrations.

引用

页数：15