Antithyroid Drug-Induced Agranulocytosis: A Case Report

被引：1
|
作者：
MacKay, Micaela [1 ]
Clewis, Madison C. [1 ]
Sweet, Patrick [1 ]
机构：
[1] Univ Texas Med Branch, Internal Med, Galveston, TX 77555 USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 11期
关键词：
graves' disease; drug -induced agranulocytosis; antithyroid drugs; agranulocytosis; drug; -reaction; methimazole; HYPERTHYROIDISM;
D O I：
10.7759/cureus.48264
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Agranulocytosis is a rare but life-threatening complication of methimazole and propylthiouracil, antithyroid drugs (ATDs) prescribed for the treatment of hyperthyroidism. We report the case of a 41-year-old female who presented to our institution with complaints of fevers, chills, sore throat, myalgias, and generalized weakness one month after treatment initiation with methimazole. A complete blood count at admission revealed agranulocytosis with an absolute neutrophil count of 0/mu l. After discontinuation of the medication, she was treated with granulocyte-colony stimulating factor and intravenous broad-spectrum antibiotics, which improved her condition on day seven of hospitalization.
引用
收藏
页数：4
相关论文
共 50 条
  • [31] Genetic variants associated with antithyroid drug-induced agranulocytosis: a genome-wide association study in a European population
    Hallberg, Par
    Eriksson, Niclas
    Ibanez, Luisa
    Bondon-Guitton, Emmanuelle
    Kreutz, Reinhold
    Carvajal, Alfonso
    Isabel Lucena, M.
    Sancho Ponce, Esther
    Molokhia, Mariam
    Martin, Javier
    Axelsson, Tomas
    Yue, Qun-Ying
    Magnusson, Patrik K. E.
    Wadelius, Mia
    LANCET DIABETES & ENDOCRINOLOGY, 2016, 4 (06) : 507 - 516
  • [32] Drug-induced agranulocytosis in the Berlin case-control surveillance study
    Huber, Matthias
    Andersohn, Frank
    Bronder, Elisabeth
    Klimpel, Andreas
    Thomae, Michael
    Konzen, Christine
    Meyer, Oliver
    Salama, Abdulgabar
    Schrezenmeier, Hubert
    Hildebrandt, Martin
    Spaeth-Schwalbe, Ernst
    Grueneisen, Andreas
    Kreutz, Reinhold
    Garbe, Edeltraut
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 70 (03) : 339 - 345
  • [33] Drug-induced agranulocytosis in rheumatology.: A study of 12 cases
    Serraj, K.
    Federici, L.
    Maloisel, F.
    Sibilia, J.
    Andres, E.
    ANNALES DE BIOLOGIE CLINIQUE, 2007, 65 (04) : 431 - 436
  • [34] How to approach drug-induced agranulocytosis in ICU
    Mahant, Seema
    Mahant, Piyu Deo
    Shobhane, Upasana
    EGYPTIAN JOURNAL OF HAEMATOLOGY, 2015, 40 (03) : 109 - 112
  • [35] Idiosyncratic drug-induced agranulocytosis or acute neutropenia
    Andres, Emmanuel
    Maloisel, Frederic
    CURRENT OPINION IN HEMATOLOGY, 2008, 15 (01) : 15 - 21
  • [36] INVESTIGATION OF PSYCHOTROPIC DRUG-INDUCED BLOOD AGRANULOCYTOSIS
    HOFFBRAND, AV
    VEYS, PA
    WILKES, S
    JOURNAL OF PSYCHOPHARMACOLOGY, 1992, 6 (02) : 222 - 224
  • [37] Clinical presentation and management of drug-induced agranulocytosis
    Andres, Emmanuel
    Zimmer, Jacques
    Mecili, Mustapha
    Weitten, Thierry
    Alt, Martine
    Maloisel, Frederic
    EXPERT REVIEW OF HEMATOLOGY, 2011, 4 (02) : 143 - 151
  • [38] antithyroid drug induced agranulocytosis: what still we need to learn ?
    PAN AFRICAN MEDICAL JOURNAL, 2016, 24
  • [39] Novel Association of KLRC4-KLRK1 Gene Polymorphisms with Susceptibility and Progression of Antithyroid Drug-Induced Agranulocytosis
    He, Yayi
    Ma, Pan
    Luo, Yuanlin
    Gong, Xiaojuan
    Gao, Jiayang
    Sun, Yuxin
    Chen, Pu
    Zhang, Suliang
    Tian, Yuxin
    Shi, Bingyin
    Zhang, Bao
    EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2024, 132 (01) : 17 - 22
  • [40] Analysis of 90 Cases of Antithyroid Drug-Induced Severe Hepatotoxicity Over 13 Years in China
    Yang, Jun
    Li, Lin-fa
    Xu, Qin
    Zhang, Jun
    Weng, Wan-wen
    Zhu, Yang-jun
    Dong, Meng-jie
    THYROID, 2015, 25 (03) : 278 - 283
12345