Anticoagulation in adult patients supported with extracorporeal membrane oxygenation: guidance from the Scientific and Standardization Committees on Perioperative and Critical Care Haemostasis and Thrombosis of the International Society on Thrombosis and Haemostasis

被引：50

作者：

Helms, Julie ^{[1
]}

Frere, Corinne ^{[2
]}

Thiele, Thomas ^{[3
]}

Tanaka, Kenichi A. ^{[4
]}

Neal, Matthew D. ^{[5
]}

Steiner, Marie E. ^{[6
,7
]}

Connors, Jean M. ^{[8
]}

Levy, Jerrold H. ^{[9
]}

机构：

[1] Strasbourg Univ UNISTRA, Strasbourg Univ Hosp, Med Intens Care Unit, NHC,INSERM,French Natl Inst Hlth & Med Res,UMR 126, Strasbourg, France

[2] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Cardiovasc Prevent Unit,UMRS 1166, F-75013 Paris, France

[3] Inst Transfusionsmed, Univ Medizin Rostock, Schillingallee 36, Rostock, Germany

[4] Univ Oklahoma, Hlth Sci Ctr, Dept Anesthesiol, Oklahoma City, OK USA

[5] Univ Pittsburgh, Trauma & Transfus Med Res Ctr, Dept Surg, Pittsburgh, PA USA

[6] Univ Minnesota, Div Hematol Oncol, Minneapolis, MN USA

[7] Univ Minnesota, Dept Pediat, Div Crit Care, Minneapolis, MN USA

[8] Harvard Med Sch, Brigham & Womens Hosp, Div Hematol, Boston, MA USA

[9] Duke Univ, Dept Anesthesiol Crit Care Surg Cardiothorac, Sch Med, Durham, NC USA

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2023年 / 21卷 / 02期

基金：

美国国家卫生研究院;

关键词：

anticoagulation; extracorporeal membrane oxygenation; critical care; PARTIAL THROMBOPLASTIN TIME; ACTIVATED CLOTTING TIME; NAFAMOSTAT MESILATE; CONVENTIONAL TESTS; LIFE-SUPPORT; HEPARIN; MANAGEMENT; BIVALIRUDIN; ARGATROBAN; THROMBOELASTOGRAPHY;

D O I：

10.1016/j.jtha.2022.11.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anticoagulation of patients supported by extracorporeal membrane oxygenation is challenging because of a high risk of both bleeding and thrombotic complications, and often empirical. Practice in anticoagulation management is therefore highly variable. The scope of this guidance document is to provide clinicians with practical advice on the choice of an anticoagulant agent, dosing, and the optimal anticoagulant monitoring strategy during extracorporeal membrane oxygenation support in adult patients.

引用

页码：373 / 396

页数：24

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