Nigella sativa supplementation normalizes serum LDL cholesterol in healthy women volunteers

Objective: To determine the effect of the powder of Nigella sativa seeds (NSS) on serum low-density lipoprotein cholesterol (LDL-C) in female volunteers.Methodology: This study included 159 female volunteers aged 30 - 35 years determine effect of various doses of Nigella sativa (NS) on LDL-C serum levels of eight groups for the duration of nine months. Subjects in the first month (October 2021) were considered as the control (C) subjects. Same subjects in the remaining eight months (November 2021 to June 2022) were administered equal daily doses (1 gram/day) of the powder of Kalonji/NSS. Blood samples were obtained and Friedewald formula was employed for determining the levels of serum LDL-C.Results: The groups 1 to 8 altogether had significant decrease in LDL-C. Analysis of variance showed highly significant variations. Intergroup variations had p > 0.0001. Various groups of LDL-C control range from 80 - 129.9 mg/dl under the influence of various doses of NS supplementation gave highly significant negative linear correlation.Conclusion: Administration of NS showed the levels of LDL-C in the central range of 80-100 mg/dl that might be considered as the physiological normal serum levels of LDL-C. Further studies are required in healthy subjects and patients having various hyperlipidaemic and other related disorders to understand the diagnostic and therapeutic significance of NS.