Status of α-emitter Radioimmunoconjugates for Targeted Therapy

被引：0
|
作者：
Mobina, Rabiei [1 ]
Alaei, Ahmad Reza Vaez [2 ]
Yousefnia, Hassan [3 ]
机构：
[1] Islamic Azad Univ, Nucl Engn Sch, Shahrood Branch, Shahrud, Iran
[2] Islamic Azad Univ, Parand Branch, Fac Sci, Tehran, Iran
[3] Nucl Sci & Technol Res Inst NSTRI, Radiat Applicat Res Sch, Tehran, Iran
来源：
CURRENT RADIOPHARMACEUTICALS | 2023年 / 16卷 / 02期
关键词：
& alpha; -emitters; radio; immunotherapy; immunoconjugates; bifunctional ligands; trials; MONOCLONAL-ANTIBODY; IN-VITRO; ALPHA-RADIOIMMUNOTHERAPY; MURINE MODEL; CANCER; ASTATINE-211; DOSIMETRY; FRAGMENTS; LYMPHOMA; F(AB')2;
D O I：
10.2174/1874471016666230106111119
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This minireview describes the global situation of ongoing research and development and the clinical application of alpha emitter labeled immunoconjugates with various alpha emitters with an overview of the future trends. The potentially helpful alpha emitter radioisotopes for medical applications, chelators, and immunomolecules of interest for future alpha radioimmunotherapy are discussed. Challenges and some suggested future works on chelators are also presented.
引用
收藏
页码：85 / 94
页数：10
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