Impact of the Cannabinoid System in Alzheimer's Disease

被引：10

作者：

Li, Shuangtao ^{[1
]}

Huang, Yuanbing ^{[2
]}

Yu, Lijun ^{[1
]}

Ji, Xiaoyu ^{[2
]}

Wu, Jie ^{[1
,3
]}

机构：

[1] Shantou Univ, Brain Funct & Dis Lab, Med Coll, 22 Rd Xinling, Shantou 515041, Guangdong, Peoples R China

[2] Yunfu Peoples Hosp, Dept Neurol, Yunfu 527300, Guangdong, Peoples R China

[3] Shantou Univ, Brain Funct & Dis Lab, Med Coll, Shantou, Peoples R China

来源：

CURRENT NEUROPHARMACOLOGY | 2023年 / 21卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Cannabinoids; CB1; receptor; CB2; endocannabinoid; neurodegenerative diseases; Alzheimer's disease; TRANSGENIC MOUSE MODEL; DRIVEN RAT MODELS; CB2; RECEPTOR; AMYLOID-BETA; MESSENGER-RNA; HUMAN BRAIN; IN-VITRO; ENDOCANNABINOID SYSTEM; FUNCTIONAL EXPRESSION; COGNITIVE IMPAIRMENT;

D O I：

10.2174/1570159X20666220201091006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cannabinoids are compounds isolated from cannabis and are also widely present in both nervous and immune systems of animals. In recent years, with in-depth research on cannabinoids, their clinical medicinal value has been evaluated, and many exciting achievements have been continuously accumulating, especially in the field of neurodegenerative disease. Alzheimer's disease is the most common type of neurodegenerative disease that causes dementia and has become a global health problem that seriously impacts human health today. In this review, we discuss the therapeutic potential of cannabinoids for the treatment of Alzheimer's disease. How cannabinoids act on different endocannabinoid receptor subtypes to regulate Alzheimer's disease and the roles of the endocannabinoid system in Alzheimer's disease are outlined, and the underlying mechanisms are discussed. Finally, we summarize the most relevant opportunities of cannabinoid pharmacology related to Alzheimer's disease and discuss the potential usefulness of cannabinoids in the clinical treatment of Alzheimer's disease.

引用

页码：715 / 726

页数：12

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