Rh(III)-catalyzed cascade annulation of 4-diazoisoquinolin-3-ones with benzoic acids to access spiro[isobenzofuran-1,4'-isoquinoline]-3,3'-diones

被引：2

作者：

Chen, Junrong ^{[1
]}

Suleman, Muhammad ^{[1
]}

Lu, Ping ^{[1
]}

Wang, Yanguang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

TETRAHEDRON | 2023年 / 137卷

基金：

中国国家自然科学基金;

关键词：

Diazo compounds; Metal carbenes; Rhodium catalysis; Heterocycles; C-H ACTIVATION/CYCLIZATION; DIAZO-COMPOUNDS; SPIRO COMPOUNDS; BOND FORMATION; N-OXIDES; INDOLES; FUNCTIONALIZATION; ISOCOUMARINS; ACTIVATION; BENZAMIDES;

D O I：

10.1016/j.tet.2023.133392

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Rh(III)-catalyzed [4 thorn 1] annulation of aromatic carboxylic acids with 4-diazoisoquinolin-3-ones is reported. A library of highly substituted spiro [isobenzofuran-1,4'-isoquinoline]-3,3'-diones were syn-thesized in moderate to good yields by this protocol (30 examples, up to 84% yield). Broad substrate scope, readily available starting materials, and mild reaction conditions are the merits of this protocol. Moreover, the reaction can be scaled up.(c) 2023 Elsevier Ltd. All rights reserved.

引用

页数：11

共 41 条

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