Rh(III)-catalyzed cascade annulation of 4-diazoisoquinolin-3-ones with benzoic acids to access spiro[isobenzofuran-1,4'-isoquinoline]-3,3'-diones

被引：2
|
作者：
Chen, Junrong [1 ]
Suleman, Muhammad [1 ]
Lu, Ping [1 ]
Wang, Yanguang [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
来源：
TETRAHEDRON | 2023年 / 137卷
基金：
中国国家自然科学基金;
关键词：
Diazo compounds; Metal carbenes; Rhodium catalysis; Heterocycles; C-H ACTIVATION/CYCLIZATION; DIAZO-COMPOUNDS; SPIRO COMPOUNDS; BOND FORMATION; N-OXIDES; INDOLES; FUNCTIONALIZATION; ISOCOUMARINS; ACTIVATION; BENZAMIDES;
D O I：
10.1016/j.tet.2023.133392
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Rh(III)-catalyzed [4 thorn 1] annulation of aromatic carboxylic acids with 4-diazoisoquinolin-3-ones is reported. A library of highly substituted spiro [isobenzofuran-1,4'-isoquinoline]-3,3'-diones were syn-thesized in moderate to good yields by this protocol (30 examples, up to 84% yield). Broad substrate scope, readily available starting materials, and mild reaction conditions are the merits of this protocol. Moreover, the reaction can be scaled up.(c) 2023 Elsevier Ltd. All rights reserved.
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页数：11
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