Vaccine-induced immune thrombotic thrombocytopenia

被引：47

作者：

Cines, Douglas B. ^{[1
,2
,4
]}

Greinacher, Andreas ^{[3
]}

机构：

[1] Perelman Univ Penn, Sch Med, Dept Pathol, Philadelphia, PA USA

[2] Perelman Univ Penn, Sch Med, Lab Med & Med, Philadelphia, PA USA

[3] Univ Med Greifswald, Inst Transfusions Med, Greifswald, Germany

[4] Dept Pathol & Lab Med, 422 Curie Blvd, Philadelphia, PA 19104 USA

来源：

BLOOD | 2023年 / 141卷 / 14期

基金：

美国国家卫生研究院;

关键词：

CHADOX1; NCOV-19; HEPARIN; ANTIBODIES; COMPLEXES; MANAGEMENT; FREQUENCY; DIAGNOSIS; BINDING; VITT; PF4;

D O I：

10.1182/blood.2022017696

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Within the first months of the COVID-19 vaccination campaign, previously healthy recipients who developed severe thrombosis (often cerebral and/or splanchnic vasculature) and thrombocytopenia typically after adenoviral vector-based vaccination were identified. Similarities between this syndrome, vaccine-induced immune thrombotic throm-bocytopenia (VITT), and heparin-induced thrombocytopenia prompted recognition of the role of antiplatelet factor 4 (PF4) antibodies and management strategies based on IV immunoglobulin and nonheparin anticoagulants, which improved outcome. We update current understanding of VITT and potential involvement of anti-PF4 antibodies in thrombotic disorders.

引用

页码：1659 / 1665

页数：7

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