Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease: Systematic Review and Meta-Analysis

被引:11
作者
Zabala-Findlay, Alex [1 ,2 ]
Penny, Lewis K. [1 ,2 ]
Lofthouse, Richard A. [1 ,2 ]
Porter, Andrew J. [1 ,2 ]
Palliyil, Soumya [1 ,2 ]
Harrington, Charles R. [1 ,3 ,4 ]
Wischik, Claude M. [1 ,3 ,4 ]
Arastoo, Mohammad [1 ,2 ]
机构
[1] Univ Aberdeen, Inst Med Sci, Aberdeen AB25 2ZD, Scotland
[2] Univ Aberdeen, Scottish Biol Facil, Aberdeen AB25 2ZP, Scotland
[3] GT Diagnost, Aberdeen AB24 5RP, Scotland
[4] TauRx Therapeut Ltd, Aberdeen AB24 5RP, Scotland
关键词
Alzheimer's disease; mild cognitive impairment; tau; biomarkers; diagnostics; blood; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; CEREBROSPINAL-FLUID; PLASMA; RECOMMENDATIONS; CSF; DEMENTIA; QUALITY;
D O I
10.3390/cells12081184
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Objectives: With the development of new technologies capable of detecting low concentrations of Alzheimer's disease (AD) relevant biomarkers, the idea of a blood-based diagnosis of AD is nearing reality. This study aims to consider the evidence of total and phosphorylated tau as blood-based biomarkers for mild cognitive impairment (MCI) and AD when compared to healthy controls. Methods: Studies published between 1 January 2012 and 1 May 2021 (Embase and MEDLINE databases) measuring plasma/serum levels of tau in AD, MCI, and control cohorts were screened for eligibility, including quality and bias assessment via a modified QUADAS. The meta-analyses comprised 48 studies assessing total tau (t-tau), tau phosphorylated at threonine 181 (p-tau181), and tau phosphorylated at threonine 217 (p-tau217), comparing the ratio of biomarker concentrations in MCI, AD, and cognitively unimpaired (CU) controls. Results: Plasma/serum p-tau181 (mean effect size, 95% CI, 2.02 (1.76-2.27)) and t-tau (mean effect size, 95% CI, 1.77 (1.49-2.04)) were elevated in AD study participants compared to controls. Plasma/serum p-tau181 (mean effect size, 95% CI, 1.34 (1.20-1.49)) and t-tau (mean effect size, 95% CI, 1.47 (1.26-1.67)) were also elevated with moderate effect size in MCI study participants compared to controls. p-tau217 was also assessed, albeit in a small number of eligible studies, for AD vs. CU (mean effect size, 95% CI, 1.89 (1.86-1.92)) and for MCI vs. CU groups (mean effect size, 95% CI, 4.16 (3.61-4.71)). Conclusions: This paper highlights the growing evidence that blood-based tau biomarkers have early diagnostic utility for Alzheimer's disease. Registration: PROSPERO No. CRD42020209482.
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页数:16
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