Deep Eutectic Solvent-Mediated Oxidative Homocoupling of Terminal Alkynes to 1,3-Diynes under Mild Green Conditions

被引:0
|
作者
Bhise, Rupali S. S. [1 ]
Ghorpade, Prashant V. V. [1 ]
Mehta, Viral R. R. [1 ]
Shankarling, Ganapati S. S. [1 ]
机构
[1] Inst Chem Technol, Dept Specialty Chem Technol, NP Marg, Mumbai 400019, India
来源
CHEMISTRYSELECT | 2023年 / 8卷 / 15期
关键词
Alkyne; C-C coupling; Deep eutectic solvents; Greener protocol; Recyclability; EFFICIENT; MIXTURES; OXIDANT;
D O I
10.1002/slct.202203985
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We prepared a commercially viable Deep Eutectic Solvent (DES) based on Choline Chloride-Urea-copper acetate for the first time. It mediates the homocoupling of terminal alkynes, using air as an oxidant. Water is the only by-product of the entire process. The method avoids ligands, bases, oxidants, and costly palladium catalysts, which qualifies the process greener than ever. The DES can be reused at least three times without affecting the reaction yield significantly. The key features of the protocol that qualify the process as green include the ambient reaction temperatures, lesser use of conventional organic solvents in the reaction, higher yields, and easy product isolation qualify the protocol as a green process.
引用
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页数:5
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