Glomerular hyperfiltration: part 2-clinical significance in children

被引：16

作者：

Adebayo, Oyindamola C. C. ^{[1
,2
]}

Nkoy, Agathe B. B. ^{[2
,3
]}

van den Heuvel, Lambertus P. P. ^{[2
,4
]}

Labarque, Veerle ^{[1
,5
]}

Levtchenko, Elena ^{[2
,6
]}

Delanaye, Pierre ^{[7
,8
]}

Pottel, Hans ^{[9
]}

机构：

[1] Katholieke Univ Leuven, Ctr Vasc & Mol Biol, Dept Cardiovasc Sci, Campus Gasthiusberg, B-3000 Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Dev & Regenerat, Lab Pediat Nephrol, Campus Gasthiusberg, B-3000 Leuven, Belgium

[3] Univ Hosp Kinshasa, Univ Kinshasa, Fac Med, Dept Pediat,Div Nephrol, Kinshasa, DEM REP CONGO

[4] Radboud Univ Nijmegen Med Ctr, Dept Pediat Nephrol, NL-6500 Nijmegen, Netherlands

[5] Univ Hosp Leuven, Dept Pediat Hematol, B-3000 Leuven, Belgium

[6] Univ Hosp Leuven, Dept Pediat Nephrol, B-3000 Leuven, Belgium

[7] Univ Liege, Dept Nephrol Dialysis Transplantat, CHU Sart Tilman, Liege, Belgium

[8] Hop Univ Caremeau, Dept Nephrol Dialysis Apheresis, Nimes, France

[9] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Campus Kulak, B-8500 Kortrijk, Belgium

来源：

PEDIATRIC NEPHROLOGY | 2023年 / 38卷 / 08期

关键词：

Glomerular hyperfiltration; Pediatric population; Diabetic kidney disease; Sickle cell disease; Solitary functioning kidney; Autosomal dominant polycystic kidney disease (ADPKD); Duchenne muscular dystrophy; Obesity-related glomerulopathy; SOLITARY FUNCTIONING KIDNEY; SICKLE-CELL NEPHROPATHY; ANGIOTENSIN-ALDOSTERONE SYSTEM; LONG-TERM CONSEQUENCES; HIGH-PROTEIN DIETS; EARLY RENAL DAMAGE; LOW-BIRTH-WEIGHT; DIABETES-MELLITUS; CLINICAL-SIGNIFICANCE; INSULIN SENSITIVITY;

D O I：

10.1007/s00467-022-05826-5

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Glomerular hyperfiltration (GHF) is a phenomenon that can occur in various clinical conditions affecting the kidneys such as sickle cell disease, diabetes mellitus, autosomal dominant polycystic kidney disease, and solitary functioning kidney. Yet, the pathophysiological mechanisms vary from one disease to another and are not well understood. More so, it has been demonstrated that GHF may occur at the single-nephron in some clinical conditions while in others at the whole-kidney level. In this review, we explore the pathophysiological mechanisms of GHF in relation to various clinical conditions in the pediatric population. In addition, we discuss the role and mechanism of action of important factors such as gender, low birth weight, and race in the pathogenesis of GHF. Finally, in this current review, we further highlight the consequences of GHF in the progression of kidney disease.

引用

页码：2529 / 2547

页数：19

共 192 条

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