New Insights in the Use of Boron Nitrogen Nanotubes as Cisplatin Nanovector

被引：1

作者：

Assas, Y. F. Z. ^{[1
]}

Belmiloud, Y. ^{[1
]}

Abdelatif, M. L. ^{[1
]}

Sehailia, M. ^{[2
]}

Rabahi, A. ^{[3
]}

Brahimi, M. ^{[1
]}

Tangour, B. ^{[4
]}

机构：

[1] Univ Sci & Technol Houari Boumediene USTHB, Lab Phys Chim Theor & Chim Informat LPCTCI, Fac Chim, BP 32, Bab Ezzouar 16111, Alger, Algeria

[2] Ctr Rech Anal Phys Chim CRAPC, BP 384, Bou Ismail 42004, Tipaza, Algeria

[3] UniversiM Sci & La Technol Houari Boumediene USTH, Lab Chim Organ Appl Grp Heterocycles, Fac Chim, BP 32, Bab Ezzouar 16111, Alger, Algeria

[4] Univ Tunis El Manar, Res Unity Modeling Fundamental Sci & Didact, Team Theoret Chem & React, Tunis, Tunisia

来源：

PHYSICAL CHEMISTRY RESEARCH | 2023年 / 11卷 / 02期

关键词：

Boron nitride nanotubes (BNNTs); Nano-vectorization; Cisplatin; DFT; NITRIDE NANOTUBES; CARBON NANOTUBES; INCLUSION COMPLEX; ANTICANCER DRUG; PLATINUM DRUGS; DELIVERY; ENCAPSULATION; CELLS; BIOCOMPATIBILITY; NANOPARTICLES;

D O I：

10.22036/pcr.2022.334140.2054

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The drug nano-vectorization is one of the objective priorities of modern medicine. A DFT study that concerns inclusion complexes between the anticancer drug cisplatin and boron nitrogen nanotubes (BNNTs) whose diameters vary from 7.35 to 12.87 angstrom is presented in this paper. The objective of the first part of the work was to highlight the different quantum phenomena that can control the chemical or physical absorption of cisplatin at the nanometric scale. The second part dealt with Nuclear Magnetic Resonance (NMR) studies that allowed the establishment of a relationship between the chemical shift (delta) of the central platinum (Pt-195) atom of the cisplatin molecule and the diameter of the used BNNT. This result can be used to monitor the concentration of cisplatin during drug filling and delivery. Finally, at a fixed diameter of the nanotube, we studied the influence of encapsulation of several cisplatin molecules and the solvent effect. We hope that this study will help in making an informed decision when choosing the diameter, the type, and length of nanotubes, based on the curative dose to be delivered to minimise drug toxicity.

引用

页码：253 / 265

页数：13

共 57 条

[1]

Achou L., 2019, Nano-Struct. Nano-Objects, V19, DOI [10.1016/j.nanoso.2019.100376, DOI 10.1016/J.NANOSO.2019.100376]

[2] Theoretical study of cisplatin binding to purine bases: Why does cisplatin prefer guanine over adenine? [J].