Total synthesis of (3R, 4S)-4-hydroxylasiodiplodin

被引:0
作者
Sheelam, Kalidasu [1 ,2 ]
Chidara, Sridhar [2 ]
Vinnakota, Srilalitha [3 ]
Sridhar, Gattu [4 ]
Polothi, Ravikumar [1 ,2 ]
机构
[1] JNT Univ, Dept Chem, Hyderabad, Telangana, India
[2] GVK Biosci Private Ltd, Hyderabad, Telangana, India
[3] ICFAI Fdn Higher Educ, Fac Sci & Technol, Dept Chem, Hyderabad, Telangana, India
[4] Kakatiya Inst Technol & Sci, Dept Chem, Warangal, Andhra Pradesh, India
关键词
Resorcylic acid lactones; (3R; 4S)-4-hydroxylasiodiplodin; Stille cross coupling; hydroboration; Yamaguchi macrolactonization; RESORCYLIC ACID LACTONES; METABOLITES; LASIODIPLODINS; MACRODIOLIDE; ZEARALENONE; KINASE;
D O I
10.1080/14786419.2021.2003354
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
An efficient stereoselective total synthesis of (3R, 4S)-4-hydroxylasiodiplodin has been accomplished starting from known starting materials. The key steps involved in this synthesis are Stille cross coupling, alkylation of 1,3-dithiane and Yamaguchi macrolactonization.
引用
收藏
页码:1277 / 1283
页数:7
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