Biological roles of RNA m7G modification and its implications in cancer

被引：21

作者：

Zhang, Xin ^{[1
]}

Zhu, Wen-Yan ^{[1
]}

Shen, Shu-Yi ^{[1
,2
]}

Shen, Jia-Hao

Chen, Xiao-Dong ^{[1
]}

机构：

[1] Nantong Univ, Sch Med, Affiliated Hosp, Dept Dermatol, Nantong, Peoples R China

[2] Fujian Med Univ, Affiliated Hosp 1, Dept Dermatol, Fuzhou, Peoples R China

来源：

BIOLOGY DIRECT | 2023年 / 18卷 / 01期

关键词：

N7-methylguanosine; Immune microenvironment; RNA methylation modification; Carcinoma; 18S RIBOSOMAL-RNA; MESSENGER-RNA; NUCLEAR EXPORT; CAPPING ENZYME; METTL1; IDENTIFICATION; METHYLATION; IMMUNE; WBSCR22/MERM1; TRANSLATION;

D O I：

10.1186/s13062-023-00414-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. In addition, there is growing evidence that m7G modifications are crucial in the emergence of cancer. Here, we review the most recent findings regarding the detection techniques, distribution, biological functions and Regulators of m7G. We also summarize the connections between m7G modifications and cancer development, drug resistance, and tumor microenvironment as well as we discuss the research's future directions and trends.

引用

页数：14