A novel donor-acceptor fluorescent probe for the fluorogenic/ chromogenic detection and bioimaging of nitric oxide

被引：4

作者：

Hu, Jingxin ^{[1
]}

Wang, Ruiya ^{[1
]}

Liao, Wantao ^{[1
]}

Hu, Jinhui ^{[1
]}

Li, Lanqing ^{[1
]}

Cheng, Zhen ^{[2
]}

Chen, Wen- Hua ^{[1
]}

机构：

[1] Wuyi Univ, Sch Pharm & Food Engn, Jiangmen 529020, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

ANALYTICA CHIMICA ACTA | 2024年 / 1296卷

关键词：

Fluorescent probe; Donor-acceptor type; Nitric oxide; Colorimetric detection; Bioimaging; SELECTIVE DETECTION; INFLAMMATION;

D O I：

10.1016/j.aca.2024.342333

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Nitric oxide (NO) plays an essential role in regulating various physiological and pathological processes. This has spurred various efforts to develop feasible methods for the detection of NO. Herein we designed and synthesized a novel donor -acceptor fluorescent probe Car -NO for the selective and specific detection of NO. Reaction of CarNO with NO generated a new donor -acceptor structure with strong intramolecular charge transfer (ICT) effect, and led to remarkable chromogenic change from yellow to blue and dramatic fluorescence quenching. Car -NO exhibited high selectivity, excellent sensitivity, and rapid response for the detection of NO. In addition, the nanoparticles prepared from Car -NO (i.e., Car -NO NPs) showed strong NIR emission and high selectivity/ sensitivity. Car -NO NPs was successfully employed to image both endogenous and exogenous NO in HeLa and RAW 264.7 cells. The present findings reveal that Car -NO is a promising probe for the detection and bioimaging of NO.

引用

页数：12

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