Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes

被引：54
作者：
Pandeya, Ankit [1 ]
Kanneganti, Thirumala-Devi [1 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2024年 / 30卷 / 01期
关键词：
MIXED LINEAGE KINASE; NLRP3; INFLAMMASOME; CELL-DEATH; GASDERMIN D; CYTOKINE STORM; CASPASE; 8; MOLECULAR SWITCH; DOMAIN-LIKE; ACTIVATION; NECROPTOSIS;
D O I：
10.1016/j.molmed.2023.10.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The innate immune system initiates cell death pathways in response to pathogens and cellular stress. Cell death can be either non-lytic (apoptosis) or lytic (PANoptosis, pyroptosis, and necroptosis). PANoptosis has been identified as an inflammatory, lytic cell death pathway driven by caspases and RIPKs that is regulated by PANoptosome complexes, making it distinct from other cell death pathways. Several PANoptosome complexes (including ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosomes) have been characterized to date. Furthermore, PANoptosis is implicated in infectious and inflammatory diseases, cancers, and homeostatic perturbations. Therefore, targeting its molecular components offers significant potential for therapeutic development. This review covers PANoptosomes and their assembly, PANoptosome-mediated cell death mechanisms, and ongoing progress in developing therapeutics that target PANoptosis.
引用
收藏
页码：74 / 88
页数：15
相关论文
共 139 条
  • [21] MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis
    Cui, Yanhui
    Wang, Xueqin
    Lin, Fengyu
    Li, Wen
    Zhao, Yuhao
    Zhu, Fei
    Yang, Hang
    Rao, Mingjun
    li, Yi
    Liang, Huaying
    Dai, Minhui
    Liu, Ben
    Chen, Lingli
    Han, Duoduo
    Lu, Rongli
    Peng, Wenzhong
    Zhang, Yan
    Song, Chao
    Luo, Yanwei
    Pan, Pinhua
    [J]. AGING AND DISEASE, 2022, 13 (03): : 899 - 909
  • [22] Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
    Degterev A.
    Huang Z.
    Boyce M.
    Li Y.
    Jagtap P.
    Mizushima N.
    Cuny G.D.
    Mitchison T.J.
    Moskowitz M.A.
    Yuan J.
    [J]. Nature Chemical Biology, 2005, 1 (2) : 112 - 119
  • [23] Identification of RIP1 kinase as a specific cellular target of necrostatins
    Degterev, Alexei
    Hitomi, Junichi
    Germscheid, Megan
    Ch'en, Irene L.
    Korkina, Olga
    Teng, Xin
    Abbott, Derek
    Cuny, Gregory D.
    Yuan, Chengye
    Wagner, Gerhard
    Hedrick, Stephen M.
    Gerber, Scott A.
    Lugovskoy, Alexey
    Yuan, Junying
    [J]. NATURE CHEMICAL BIOLOGY, 2008, 4 (05) : 313 - 321
  • [24] Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition
    Dekker, Carien
    Mattes, Henri
    Wright, Michael
    Boettcher, Andreas
    Hinniger, Alexandra
    Hughes, Nicola
    Kapps-Fouthier, Sandra
    Eder, Jorg
    Erbel, Paulus
    Stiefl, Nikolaus
    Mackay, Angela
    Farady, Christopher J.
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2021, 433 (24)
  • [25] Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice
    Dempsey, C.
    Araiz, A. Rubio
    Bryson, K. J.
    Finucane, O.
    Larkin, C.
    Mills, E. L.
    Robertson, A. A. B.
    Cooper, M. A.
    O'Neill, L. A. J.
    Lynch, M. A.
    [J]. BRAIN BEHAVIOR AND IMMUNITY, 2017, 61 : 306 - 316
  • [26] Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection
    Doerflinger, Marcel
    Deng, Yexuan
    Whitney, Paul
    Salvamoser, Ranja
    Engel, Sven
    Kueh, Andrew J.
    Tai, Lin
    Bachem, Annabell
    Gressier, Elise
    Geoghegan, Niall D.
    Wilcox, Stephen
    Rogers, Kelly L.
    Garnham, Alexandra L.
    Dengler, Michael A.
    Bader, Stefanie M.
    Ebert, Gregor
    Pearson, Jaclyn S.
    De Nardo, Dominic
    Wang, Nancy
    Yang, Chenying
    Pereira, Milton
    Bryant, Clare E.
    Strugnell, Richard A.
    Vince, James E.
    Pellegrini, Marc
    Strasser, Andreas
    Bedoui, Sammy
    Herold, Marco J.
    [J]. IMMUNITY, 2020, 53 (03) : 533 - +
  • [27] Protective effect of NSA on intestinal epithelial cells in a necroptosis model
    Dong, Wei
    Zhang, Min
    Zhu, Yaxi
    Chen, Yuanhan
    Zhao, Xingchen
    Li, Ruizhao
    Zhang, Li
    Ye, Zhiming
    Liang, Xingling
    [J]. ONCOTARGET, 2017, 8 (49) : 86726 - 86735
  • [28] Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance the Expression of a Subset of NF-κB Target Genes
    Erener, Sueheda
    Petrilli, Virginie
    Kassner, Ingrid
    Minotti, Roberta
    Castillo, Rosa
    Santoro, Raffaella
    Hassa, Paul O.
    Tschopp, Juerg
    Hottigert, Michael O.
    [J]. MOLECULAR CELL, 2012, 46 (02) : 200 - 211
  • [29] Novel RIPK3 inhibitors discovered through a structure-based approach exert post-ischemic neuroprotection
    Fayaz, S. M.
    Kumar, V. S. Suvanish
    Davis, Charles K.
    Rajanikant, G. K.
    [J]. MOLECULAR DIVERSITY, 2016, 20 (03) : 719 - 728
  • [30] Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma
    Fianco, Giulia
    Contadini, Claudia
    Ferri, Alessandra
    Cirotti, Claudia
    Stagni, Venturina
    Barila, Daniela
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (12)
12345678910