Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory

被引:3
作者
San Agustin, Arantzazu [1 ,2 ,3 ,4 ]
Crevillen, David [1 ]
Soto-Leon, Vanesa [5 ]
Moreno, Juan C. [1 ]
Oliviero, Antonio [5 ,6 ]
Pons, Jose L. [3 ,4 ]
机构
[1] CSIC, Cajal Inst, Neural Rehabil Grp NRG, Madrid, Spain
[2] Univ Autonoma Madrid, Cajal Inst, PhD Program Neurosci, Madrid, Spain
[3] Northwestern Univ, Feinberg Sch Med, Dept Phys Med & Rehabil, Chicago, IL 60625 USA
[4] Shirley Ryan AbilityLab, Legs & Walking AbilityLab, Chicago, IL 60611 USA
[5] SESCAM, Hosp Nacl Paraplej, FENNSI Grp, Toledo, Spain
[6] Hosp Madronos, Ctr Clin Neurosci, Brunete, Spain
关键词
MEDIAL TEMPORAL-LOBE; WORKING-MEMORY; PREFRONTAL CORTEX; INFORMATION; IMPAIRMENT; PLASTICITY; CAPACITY; AMNESIA; ORDER; LONG;
D O I
10.1371/journal.pone.0295413
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The hippocampus is a fundamental cortical structure in the memory process of encoding, retaining, and recalling information. Transcranial Magnetic Stimulation (TMS) following a Paired Associative Stimulation (PAS) enhances nervous system excitability and promotes cortical plasticity mechanisms by synchronizing two stimuli in the same neural pathway. However, PAS has not been shown to improve memorization capacity yet. Here, we present an innovative protocol stemming from the PAS paradigm, which combines single-pulse TMS to the hippocampus with endogenous hippocampal activity during a working memory (WM) task. 96 volunteers were randomized across one experimental group and three parallel groups (motor cortex stimulation, sham stimulation, and no stimulation) in a single session. This combined-stimuli configuration resulted in an increased memorization capacity in the WM task, which was dependent on the stimulated brain location and subjects' basal memory performance. These results are potentially significant for clinical research on memory dysfunction and its related neurological disorders. Future research on paired associative or combined stimulation is required to unveil stimulation-derived neural mechanisms that enhance the ability to memorize.
引用
收藏
页数:18
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