IL-2-driven CD8+T cell phenotypes: implications for immunotherapy

被引：27

作者：

Niederlova, Veronika ^{[1
]}

Tsyklauri, Oksana ^{[1
]}

Kovar, Marek ^{[2
]}

Stepanek, Ondrej ^{[1
]}

机构：

[1] Czech Acad Sci, Inst Mol Genet, Lab Adapt Immun, Prague, Czech Republic

[2] Czech Acad Sci, Inst Microbiol, Lab Tumor Immunol, Prague, Czech Republic

来源：

TRENDS IN IMMUNOLOGY | 2023年 / 44卷 / 11期

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

REGULATORY T-CELLS; IN-VIVO EXPANSION; IL-2; RECEPTOR; RECOMBINANT INTERLEUKIN-2; SELECTIVE STIMULATION; TUMOR; COMPLEXES; CYTOKINE; EXPRESSION; ANTIBODY;

D O I：

10.1016/j.it.2023.09.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The therapeutic potential of interleukin (IL)-2 in cancer treatment has been known for decades, yet its widespread adoption in clinical practice remains limited. Recently, chimeric proteins of an anti-PD-1 antibody and suboptimal IL-2 variants were shown to stimulate potent antitumor and antiviral immunity by inducing unique effector CD8+ T cells in mice. A similar subset of cytotoxic T cells is induced by depletion of regulatory T cells (Tregs), suggesting IL-2 sequestration as a major mechanism through which regulatory T cells suppress activated CD8+ T cells. Here, we present our view of how IL-2-based biologicals can boost the antitumor response at a cellular level, and propose that the role of Tregs following such treatments may have been previously overestimated.

引用

页码：890 / 901

页数：12

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