Introduction: Little is known about the relationship of sleep, personality and Academic Performance (RA) in students. Objective: To explore the relationship between sleep, chronotype, anxiety, personality, quality of life, and RA in university students. Method: The study was quantitative, observational crosssectional. Cumulative RA (RAA), physiological sleep parameters, sleep quality index, chronotype, personality, anxiety and quality of life were explored in university students. Comparison and multiple linear regression were performed. Results: In a sample of 27 students, the following were found: Significant positive correlations between RAA and sex and sleep duration; variance for age, sleep, anxiety, attention to norms and sensitivity; significant effect in age and standard deviation of sleep, on the variance of the RAA (p=.001) with 39.1% to 50.8% of causality (R(2)a= .391; R2= .508). Conclusions: The RAA in youth is moderated by sleep duration and sleep activity is sensitive to identifying significant changes in RAA. The index of sleep quality, chronotype, personality, anxiety and quality of life are not susceptible to identifying significant effects on the RAA in students. It is recommended to continue research in this area with larger samples.