KRT15 in early breast cancer screening and correlation with HER2 positivity, pathological grade and N stage

被引：4
作者：
Zhang, Zijing [1 ]
Wang, Hongying [1 ]
Jin, Yiting [1 ]
Zhou, Jian [1 ]
Chu, Chengyu [1 ]
Tang, Feng [2 ]
Zou, Liping [2 ]
Zou, Qiang [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai 200040, Peoples R China
[2] Fudan Univ, Huashan Hosp, Dept Pathol, Shanghai 200040, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2023年 / 17卷 / 12期
关键词：
distinguishing ability; ductal carcinoma in situ; ductal carcinoma in situ with microinvasion; invasive breast cancer; KRT15;
D O I：
10.2217/bmm-2023-0130
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective: This study was designed to explore KRT15 dysregulation and its correlation with clinical characteristics among ductal carcinoma in situ (DCIS), DCIS with microinvasion (DCIS-MI) and invasive breast cancer (IBC) patients.Methods: KRT15 from lesion samples of 50 DCIS patients, 48 DCIS-MI patients and 50 IBC patients was detected by immunohistochemistry.Results: KRT15 discriminated IBC patients from DCIS patients (area under the curve [AUC] = 0.895; 95% CI = 0.836-0.954) and DCIS-MI patients (AUC = 0.707; 95% CI = 0.606-0.808). In DCIS patients, KRT15 was negatively correlated with pathological grade (p = 0.015). In DCIS-MI patients, KRT15 was positively related to estrogen receptor positivity but negatively associated with Ki-67 (both p < 0.05). In IBC patients, KRT15 was negatively linked to HER2 positivity, histological grade, N stage and tumor node metastasis stage (all p < 0.05). Conclusion: KRT15 assessment may help with early breast cancer screening.
引用
收藏
页码：553 / 562
页数：10
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