An integrated overview of the immunosuppression features in the tumor microenvironment of pancreatic cancer

被引：8
作者：
Guo, Jinglong [1 ]
Wang, Siyue [2 ]
Gao, Qi [1 ]
机构：
[1] First Hosp Jilin Univ, Dept Cardiovasc Dis, Changchun, Peoples R China
[2] Baylor Coll Med, One Baylor Pl, Houston, TX USA
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
pancreatic cancer; complex tumor microenvironment; diverse cellular cross-regulations; immunosuppression features; targeting strategy; REGULATORY T-CELLS; TISSUE-RESIDENT MACROPHAGES; IMPROVES SURVIVAL; DUCTAL ADENOCARCINOMA; SUPPRESSOR-CELLS; MAST-CELLS; TH17; CELLS; OPEN-LABEL; IMMUNOTHERAPY; CYCLOPHOSPHAMIDE;
D O I：
10.3389/fimmu.2023.1258538
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies. It is characterized by a complex and immunosuppressive tumor microenvironment (TME), which is primarily composed of tumor cells, stromal cells, immune cells, and acellular components. The cross-interactions and -regulations among various cell types in the TME have been recognized to profoundly shape the immunosuppression features that meaningfully affect PDAC biology and treatment outcomes. In this review, we first summarize five cellular composition modules by integrating the cellular (sub)types, phenotypes, and functions in PDAC TME. Then we discuss an integrated overview of the cross-module regulations as a determinant of the immunosuppressive TME in PDAC. We also briefly highlight TME-targeted strategies that potentially improve PDAC therapy.
引用
收藏
页数：15
相关论文
共 131 条
  • [1] ZEB1 and IL-6/11-STAT3 signalling cooperate to define invasive potential of pancreatic cancer cells via differential regulation of the expression of S100 proteins
    Al-Ismaeel, Qais
    Neal, Christopher P.
    Al-Mahmoodi, Hanaa
    Almutairi, Zamzam
    Al-Shamarti, Ibtihal
    Straatman, Kees
    Jaunbocus, Nabil
    Irvine, Andrew
    Issa, Eyad
    Moreman, Catherine
    Dennison, Ashley R.
    Sayan, A. Emre
    McDearmid, Jonathan
    Greaves, Peter
    Tulchinsky, Eugene
    Kriajevska, Marina
    [J]. BRITISH JOURNAL OF CANCER, 2019, 121 (01) : 65 - 75
  • [2] Overcoming immunotherapeutic resistance in PDAC: SIRP?-CD47 blockade
    Alausa, Abdullahi
    Lawal, Khadijat Ayodeji
    Babatunde, Oluwakemi Arinola
    Obiwulu, E. N. O.
    Oladokun, Olajumoke Christianah
    Fadahunsi, Olumide Samuel
    Celestine, Ugwu Obiora
    Moses, Emmanuel Ugbede
    Akaniro, Ifunanya Rejoice
    Adegbola, Peter Ifeoluwa
    [J]. PHARMACOLOGICAL RESEARCH, 2022, 181
  • [3] Genomic analyses identify molecular subtypes of pancreatic cancer
    Bailey, Peter
    Chang, David K.
    Nones, Katia
    Johns, Amber L.
    Patch, Ann-Marie
    Gingras, Marie-Claude
    Miller, David K.
    Christ, Angelika N.
    Bruxner, Tim J. C.
    Quinn, Michael C.
    Nourse, Craig
    Murtaugh, L. Charles
    Harliwong, Ivon
    Idrisoglu, Senel
    Manning, Suzanne
    Nourbakhsh, Ehsan
    Wani, Shivangi
    Fink, Lynn
    Holmes, Oliver
    Chin, Vencssa
    Anderson, Matthew J.
    Kazakoff, Stephen
    Leonard, Conrad
    Newell, Felicity
    Waddell, Nick
    Wood, Scott
    Xu, Qinying
    Wilson, Peter J.
    Cloonan, Nicole
    Kassahn, Karin S.
    Taylor, Darrin
    Quek, Kelly
    Robertson, Alan
    Pantano, Lorena
    Mincarelli, Laura
    Sanchez, Luis N.
    Evers, Lisa
    Wu, Jianmin
    Pinese, Mark
    Cowley, Mark J.
    Jones, Marc D.
    Colvin, Emily K.
    Nagrial, Adnan M.
    Humphrey, Emily S.
    Chantrill, Lorraine A.
    Mawson, Amanda
    Humphris, Jeremy
    Chou, Angela
    Pajic, Marina
    Scarlett, Christopher J.
    [J]. NATURE, 2016, 531 (7592) : 47 - +
  • [4] Therapeutic targeting of tumour myeloid cells
    Barry, Simon T.
    Gabrilovich, Dmitry I.
    Sansom, Owen J.
    Campbell, Andrew D.
    Morton, Jennifer P.
    [J]. NATURE REVIEWS CANCER, 2023, 23 (04) : 216 - 237
  • [5] Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer
    Bayne, Lauren J.
    Beatty, Gregory L.
    Jhala, Nirag
    Clark, Carolyn E.
    Rhim, Andrew D.
    Stanger, Ben Z.
    Vonderheide, Robert H.
    [J]. CANCER CELL, 2012, 21 (06) : 822 - 835
  • [6] Challenges and Opportunities for Pancreatic Cancer Immunotherapy
    Bear, Adham S.
    Vonderheide, Robert H.
    O'Hara, Mark H.
    [J]. CANCER CELL, 2020, 38 (06) : 788 - 802
  • [7] Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6Clow F4/80+ Extratumoral Macrophages
    Beatty, Gregory L.
    Winograd, Rafael
    Evans, Rebecca A.
    Long, Kristen B.
    Luque, Santiago L.
    Lee, Jae W.
    Clendenin, Cynthia
    Gladney, Whitney L.
    Knoblock, Dawson M.
    Guirnalda, Patrick D.
    Vonderheide, Robert H.
    [J]. GASTROENTEROLOGY, 2015, 149 (01) : 201 - 210
  • [8] CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
    Beatty, Gregory L.
    Chiorean, Elena G.
    Fishman, Matthew P.
    Saboury, Babak
    Teitelbaum, Ursina R.
    Sun, Weijing
    Huhn, Richard D.
    Song, Wenru
    Li, Dongguang
    Sharp, Leslie L.
    Torigian, Drew A.
    O'Dwyer, Peter J.
    Vonderheide, Robert H.
    [J]. SCIENCE, 2011, 331 (6024) : 1612 - 1616
  • [9] Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression
    Bernard, Vincent
    Semaan, Alexander
    Huang, Jonathan
    San Lucas, F. Anthony
    Mulu, Feven C.
    Stephens, Bret M.
    Guerrero, Paola A.
    Huang, Yanqing
    Zhao, Jun
    Kamyabi, Nabiollah
    Sen, Subrata
    Scheet, Paul A.
    Taniguchi, Cullen M.
    Kim, Michael P.
    Tzeng, Ching-Wei
    Katz, Matthew H.
    Singhi, Aatur D.
    Maitra, Anirban
    Alvarez, Hector A.
    [J]. CLINICAL CANCER RESEARCH, 2019, 25 (07) : 2194 - 2205
  • [10] Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via TNF in Pancreatic Cancer
    Bianchi, Anna
    Silva, Iago De Castro
    Deshpande, Nilesh U.
    Singh, Samara
    Mehra, Siddharth
    Garrido, Vanessa T.
    Guo, Xinyu
    Nivelo, Luis A.
    Kolonias, Despina S.
    Saigh, Shannon J.
    Wieder, Eric
    Rafie, Christine I.
    Dosch, Austin R.
    Zhou, Zhiqun
    Umland, Oliver
    Amirian, Haleh
    Ogobuiro, Ifeanyichukwu C.
    Zhang, Jian
    Ban, Yuguang
    Shiau, Carina
    Nagathihalli, Nagaraj S.
    Montgomery, Elizabeth A.
    Hwang, William L.
    Brambilla, Roberta
    Komanduri, Krishna
    V. Villarino, Alejandro
    Toska, Eneda
    Stanger, Ben Z.
    Gabrilovich, Dmitry I.
    Merchant, Nipun B.
    Datta, Jashodeep
    [J]. CANCER DISCOVERY, 2023, 13 (06) : 1428 - 1453
12345678910