Macrophage polarization in bone implant repair: A review

被引：13
作者：
Song, Zhengzheng [1 ,3 ]
Cheng, Yuxi [1 ,3 ]
Chen, Minmin [1 ]
Xie, Xiaoli [1 ,2 ,4 ]
机构：
[1] Cent South Univ, Xiangya Stomatol Hosp, Changsha 410078, Hunan, Peoples R China
[2] Hunan Key Lab Oral Hlth Res, Changsha 410008, Hunan, Peoples R China
[3] Cent South Univ, Xiangya Sch Stomatol, Changsha 410008, Hunan, Peoples R China
[4] Xiangya Stomatol Hosp, 72, Xiangya Rd, Changsha, Hunan, Peoples R China
来源：
TISSUE & CELL | 2023年 / 82卷
关键词：
Macrophage; Bone implant; Osteogenesis; Angiogenesis; MESENCHYMAL STEM-CELLS; TISSUE-REPAIR; OSTEOGENIC DIFFERENTIATION; M2; POLARIZATION; ACTIVATION; EXOSOMES; METABOLISM; MONOCYTES; DISEASES; HEALTH;
D O I：
10.1016/j.tice.2023.102112
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Macrophages (MO) are highly adaptable and functionally polarized cells that play a crucial role in various physiological and pathological processes. Typically, MO differentiate into two distinct subsets: the proinflammatory (M1) and anti-inflammatory (M2) phenotypes. Due to their potent immunomodulatory and antiinflammatory properties, MO have garnered significant attention in recent decades. In the context of bone implant repair, the immunomodulatory function of MO is of paramount importance. Depending on their polarization phenotype, MO can exert varying effects on osteogenesis, angiogenesis, and the inflammatory response around the implant. This paper provides an overview of the immunomodulatory and inflammatory effects of MO polarization in the repair of bone implants.
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页数：11
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